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· 范兒1258—「The Holy Grail」2
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· 范兒1255—「認同感」:恆心與自
· 范兒1254—「擼串」:恆心與自律
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· 范兒1257—「川普」33:恆心與自
· 范兒1256—「同性婚姻」2:恆心
· 范兒1255—「認同感」:恆心與自
· 范兒1254—「擼串」:恆心與自律
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范兒766——乳腺癌4:恆心與自律是成功人生的永恆的原動力
   

藤兒點評:乳腺癌一詞會嚇破一個女人的膽。然而,更可怕的是,即使沒有死於乳腺癌,經過手術、放療和化療之後,倖存下來的乳腺癌患者卻要進一步地承受“化療腦”的巨大痛苦折磨......

所謂的“化療腦”指的是接受化療的癌症患者會出現記憶力和其它認知功能下降等副作用,美國密蘇里大學一項新研究發現,接受化療的患者練習太極拳有助於防止“化療腦”(chemo brain)。

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來源:Vancouver Sun 2015-04-27

UBC research looks at effects of ‘chemo brain’

UBC research looks at effects of ‘chemo brain’

A current study at the BC Cancer Agency focuses on women who have breast cancer with the NExT program (Nutrition and Exercise during treatment). Marita Luk is a breast cancer survivor who participates in this program, and is facilitated by Kelcey Bland who makes sure the fitness routines are done properly.

Photograph by: Kim Stallknecht , Vancouver Sun

Partway through her treatment for breast cancer, Marita Luk noticed she was starting to forget things.

“I had to write down almost everything I was doing … things like ‘Don’t forget your pills’,” she said.

“At first I thought, maybe it’s because I’m getting old.”

But when Luk, who is in her mid-40s, spoke with other women undergoing chemotherapy, she learned that what she was experiencing is a common phenomenon nicknamed “chemo brain.”

New research out of UBC confirms that breast cancer patients who have undergone chemotherapy have more trouble focusing their minds on the tasks in front of them than healthy women do.

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“You don’t even know when it’s coming on. It really feels like a fog in your head,” Luk said.

The UBC researchers, whose work was published recently in the journal Clinical Neurophysiology, used an electroencephalogram (EEG) to monitor the brain activity of breast cancer patients while they completed a series of tasks.

“A healthy brain spends some time wandering and some time engaged,” UBC psychology professor Todd Handy said in a news release. “We found that ‘chemo brain’ is a chronically wandering brain. They’re essentially stuck in a shut-out mode.”

According to Handy, healthy brains tend to engage completely with a task for a few seconds before wandering for a bit. People with chemo brain tend to stay in that state of wandering.

Even when the women who participated in the study thought they were totally focused on a task, readouts from an electroencephalogram (EEG) showed that a large part of their brains were turned off and their minds were wandering.

The research also showed that when the cancer patients were asked to relax, their brains were more active than those of healthy women.

The psychologists suggest that this research could help doctors measure the impact of chemotherapy on the brain and monitor whether patients are improving over time.

“Physicians now recognize that the effects of cancer treatment persist long after it is over and these effects can really impact a person’s life,” said co-author Kristin Campbell.

As for Luk, she has felt her mind gradually growing sharper since her treatment ended about a year ago and she is beginning to feel more confident in her job as the business development manager for BCIT’s School of Construction and the Environment.

Her experience with chemo brain has taught her the importance of memory and keeping records for the future.

“Now I tend to be the person taking photos all the time,” she said.

The UBC research received funding from the Canadian Breast Cancer Foundation for BC/Yukon.

blindsay@vancouversun.com

Twitter.com/bethanylindsay

UBC∶化療腦 確實存在

UBC研究者認為,「化療腦」確實存在。(UBC Julia Kam 提供)

UBC研究者認為,「化療腦」確實存在。(UBC Julia Kam 提供)


卑詩大學(UBC)一份最新報告指出,化療後出現「化療腦」情況的確存在,除了出現記憶力和其他認知功能衰退外,還有一項副作用是無法集中注意力。

UBC心理學教授漢迪(Dr. Todd Handy)在醫學雜搖窩linical Neurophysiology」發表的報告指出,一個正常的大腦,會花一些時間思考,一些時間參與,而「化療腦」則常常處在游離狀態,有時會突然進入「死機」狀態。

漢迪舉例稱,大多數人的腦部運動都是循環模式,一旦確立目標,下一步將集中注意力完成。而那些依賴化療戰勝癌症的人士,他們的大腦則在一個不斷反思的狀態。

研究者邀請一些乳癌患者及健康人士接受試驗,並監控她們的大腦活動。那些接受化療者,大腦完全無法持續集中注意力,即使她們自認為已經執行任務,但大腦反映出的卻是完全相反的結果。當參與實驗者被要求放鬆時,接受化療人士的腦部仍有很多活動。

研究者認為,他們的研究成果可以幫助腫瘤專家及一線的醫療人士了解化療對病人大腦產生的影響。

副教授坎貝爾(Kristin Campbell)指出,通過這一研究,醫生們可以知道,用化療對抗腫瘤,產生的負面作用持續時間可能很長,對病人生活產生很大影響。

改變基因 或可預防腦腫脹

麥維卡。(取自UBC網站)

麥維卡。(取自UBC網站)

卑詩大學(UBC)莫瓦法吉恩大腦健康中心(Djavad Mowafaghian Centre for Brain Health)的科學家,與UBC及溫哥華沿岸衛生局(Vancouver Coastal Health)合作研究發現,只須改變一個基因,或許可以阻止齧齒動物出現腦腫脹。

這項研究23日在Cell醫學雜誌發表,防止因為中風、感染、頭部受傷、心搏驟停等導致腦腫脹的研究,開啟一個新的篇章。

因為受傷,產生的氯化鈉在數日內迅速蔓延神經系統,導致腦細胞死亡,威脅生命。

該研究項目共同負責人、腦部專家麥維卡(Brian MacVicaar)指出,人們都知道氯化鈉在神經元的累積,是導致腦腫脹的原因,現在找到目標,或許就能阻止腦腫脹。

研究發現,只要改變一個基因,就能阻止氯化鈉在神經細胞的聚集,讓腦細胞不至於死亡。儘管科學家們目前使用的方法,不足以在最短時間內阻止腦腫脹發生,但對這方面的藥物研究,提供了一個新方向。

 
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