Poppaea was married first to Rufrius Crispinus, then to the future emperor Otho. When Poppaea became mistress of the emperor Nero, Otho's friend, Nero appointed Otho to an important post as governor of Lusitai. Nero married Poppaea, and Poppaea was given the title Augusta. Poppaea and Nero had a daughter, Claudia, who did not live long.

Poppaea urged Nero to kill his mother, Agrippina the Younger, and to divorce and later murder his first wife, Octavia. She is also reported to have persuaded Nero to kill the philosopher Seneca, who had supported Nero's previous mistress, Acte Claudia. Nero supposedly kicked her when she was pregnant in 65 C.E. and she died.

Billon tetradrachm, AD 54-68 (year 10 = AD 64) . 11.79gm, 24mm. Radiate head of Nero right / Bust of Poppaea right. Emmett 128 (10); Milne 218. F+ with some corrosion on reverse. Ex - Sayles, he purchased from C. & L. Deland in 1973.