自閉症特徵與中年和老年自殺傾向：探究心理健康和社會聯繫的中介作用 Autistic traits and suicidality in midlife and old age: investigating mediating effects of mental health and social connectedness ——《自然 / 心理健康》第4卷，第2期，2026年2月—— <Nature / Mental Health> Volume 4, Issue 2, Feb. 2026 【摘要】中老年自閉症患者的自殺傾向有所增加，但人們對自閉症與中老年自殺傾向之間潛在聯繫的因素知之甚少。本研究報告了一項橫斷面觀察性研究，納入了9979名50歲及以上的成年人（76%為女性），他們完成了測量自閉症特徵、當前心理健康狀況、社會聯繫和自殺傾向（自殺意念和自殺性自傷）的問卷調查。我們採用路徑分析法探討了自閉症特徵與自殺傾向之間的關係，以及當前心理健康狀況、社會聯繫和性別（男性/女性）的中介作用。結果發現，抑鬱、焦慮、創傷後應激障礙（PTSD）、孤獨感和社會孤立均顯著中介了自閉症特徵與自殺意念之間的關係，但效應量較小。對於自殺性自傷，男性、抑鬱、PTSD和社會孤立被發現是中介因素。我們得出結論，心理健康問題和社會孤立是導致50歲以上具有高度自閉症特徵人群自殺率升高的誘因。針對自閉症譜系人群，在其一生中開展有針對性的、個體化的干預措施至關重要。 [Abstract] Suicidality is increased among middle-aged and older autistic adults, but little is known about the underlying factors linking autism with suicidality in midlife and older age. Here we report a cross-sectional observational study of 9,979 adults (76% female) aged 50+ years who completed questionnaires measuring autistic traits, current mental health, social connections and suicidality (suicidal ideation and suicidal self-harm). We use path analysis to explore the relationship between autistic traits and suicidality and the mediating effects of current mental health, social connectedness and male/female sex. Our results find that depression, anxiety, post-traumatic stress disorder (PTSD), loneliness and social isolation all significantly mediate the relationship between autistic traits and suicidal ideation, with small effect sizes. For suicidal self-harm, male sex, depression, PTSD and social isolation were found to be mediators. We conclude that mental health difficulties and social isolation mediate higher rates of suicidality in 50+-year-olds with high autistic traits. Targeted and individually tailored interventions for people on the autism spectrum across the lifespan are important. 論文原文：Eleanor Nuzum, Radvile Medeisyte, Aphrodite Eshetu, et al (2026). Autistic traits and suicidality in midlife and old age: investigating mediating effects of mental health and social connectedness. Nature / Mental Health. Volume 4, Issue 2, Pages 255–262. February 2026. https://doi.org/10.1038/s44220-025-00579-0 （翻譯兼責任編輯：MARY） （需要英文原文的朋友，請聯繫微信：millerdeng95或iacmsp）
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