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藤儿的博客  
不积跬步,无以至千里;不积小流,无以成江海。  
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范儿766——乳腺癌4:恒心与自律是成功人生的永恒的原动力 2015-04-28 20:11:17

藤儿点评:乳腺癌一词会吓破一个女人的胆。然而,更可怕的是,即使没有死于乳腺癌,经过手术、放疗和化疗之后,幸存下来的乳腺癌患者却要进一步地承受“化疗脑”的巨大痛苦折磨......

所谓的“化疗脑”指的是接受化疗的癌症患者会出现记忆力和其它认知功能下降等副作用,美国密苏里大学一项新研究发现,接受化疗的患者练习太极拳有助于防止“化疗脑”(chemo brain)。

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来源:Vancouver Sun 2015-04-27

UBC research looks at effects of ‘chemo brain’

UBC research looks at effects of ‘chemo brain’

A current study at the BC Cancer Agency focuses on women who have breast cancer with the NExT program (Nutrition and Exercise during treatment). Marita Luk is a breast cancer survivor who participates in this program, and is facilitated by Kelcey Bland who makes sure the fitness routines are done properly.

Photograph by: Kim Stallknecht , Vancouver Sun

Partway through her treatment for breast cancer, Marita Luk noticed she was starting to forget things.

“I had to write down almost everything I was doing … things like ‘Don’t forget your pills’,” she said.

“At first I thought, maybe it’s because I’m getting old.”

But when Luk, who is in her mid-40s, spoke with other women undergoing chemotherapy, she learned that what she was experiencing is a common phenomenon nicknamed “chemo brain.”

New research out of UBC confirms that breast cancer patients who have undergone chemotherapy have more trouble focusing their minds on the tasks in front of them than healthy women do.

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“You don’t even know when it’s coming on. It really feels like a fog in your head,” Luk said.

The UBC researchers, whose work was published recently in the journal Clinical Neurophysiology, used an electroencephalogram (EEG) to monitor the brain activity of breast cancer patients while they completed a series of tasks.

“A healthy brain spends some time wandering and some time engaged,” UBC psychology professor Todd Handy said in a news release. “We found that ‘chemo brain’ is a chronically wandering brain. They’re essentially stuck in a shut-out mode.”

According to Handy, healthy brains tend to engage completely with a task for a few seconds before wandering for a bit. People with chemo brain tend to stay in that state of wandering.

Even when the women who participated in the study thought they were totally focused on a task, readouts from an electroencephalogram (EEG) showed that a large part of their brains were turned off and their minds were wandering.

The research also showed that when the cancer patients were asked to relax, their brains were more active than those of healthy women.

The psychologists suggest that this research could help doctors measure the impact of chemotherapy on the brain and monitor whether patients are improving over time.

“Physicians now recognize that the effects of cancer treatment persist long after it is over and these effects can really impact a person’s life,” said co-author Kristin Campbell.

As for Luk, she has felt her mind gradually growing sharper since her treatment ended about a year ago and she is beginning to feel more confident in her job as the business development manager for BCIT’s School of Construction and the Environment.

Her experience with chemo brain has taught her the importance of memory and keeping records for the future.

“Now I tend to be the person taking photos all the time,” she said.

The UBC research received funding from the Canadian Breast Cancer Foundation for BC/Yukon.

blindsay@vancouversun.com

Twitter.com/bethanylindsay

UBC∶化疗脑 确实存在

UBC研究者认为,「化疗脑」确实存在。(UBC Julia Kam 提供)

UBC研究者认为,「化疗脑」确实存在。(UBC Julia Kam 提供)


卑诗大学(UBC)一份最新报告指出,化疗後出现「化疗脑」情况的确存在,除了出现记忆力和其他认知功能衰退外,还有一项副作用是无法集中注意力。

UBC心理学教授汉迪(Dr. Todd Handy)在医学杂摇窩linical Neurophysiology」发表的报告指出,一个正常的大脑,会花一些时间思考,一些时间参与,而「化疗脑」则常常处在游离状态,有时会突然进入「死机」状态。

汉迪举例称,大多数人的脑部运动都是循环模式,一旦确立目标,下一步将集中注意力完成。而那些依赖化疗战胜癌症的人士,他们的大脑则在一个不断反思的状态。

研究者邀请一些乳癌患者及健康人士接受试验,并监控她们的大脑活动。那些接受化疗者,大脑完全无法持续集中注意力,即使她们自认为已经执行任务,但大脑反映出的却是完全相反的结果。当参与实验者被要求放松时,接受化疗人士的脑部仍有很多活动。

研究者认为,他们的研究成果可以帮助肿瘤专家及一线的医疗人士了解化疗对病人大脑产生的影响。

副教授坎贝尔(Kristin Campbell)指出,通过这一研究,医生们可以知道,用化疗对抗肿瘤,产生的负面作用持续时间可能很长,对病人生活产生很大影响。

改变基因 或可预防脑肿胀

麦维卡。(取自UBC网站)

麦维卡。(取自UBC网站)

卑诗大学(UBC)莫瓦法吉恩大脑健康中心(Djavad Mowafaghian Centre for Brain Health)的科学家,与UBC及温哥华沿岸卫生局(Vancouver Coastal Health)合作研究发现,只须改变一个基因,或许可以阻止啮齿动物出现脑肿胀。

这项研究23日在Cell医学杂志发表,防止因为中风、感染、头部受伤、心搏骤停等导致脑肿胀的研究,开启一个新的篇章。

因为受伤,产生的氯化钠在数日内迅速蔓延神经系统,导致脑细胞死亡,威胁生命。

该研究项目共同负责人、脑部专家麦维卡(Brian MacVicaar)指出,人们都知道氯化钠在神经元的累积,是导致脑肿胀的原因,现在找到目标,或许就能阻止脑肿胀。

研究发现,只要改变一个基因,就能阻止氯化钠在神经细胞的聚集,让脑细胞不至於死亡。尽管科学家们目前使用的方法,不足以在最短时间内阻止脑肿胀发生,但对这方面的药物研究,提供了一个新方向。

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