The therapies used in China for curing Covid-19-風蕭蕭-萬維博客-萬維讀者網（電腦版）

This article discussed reason why pandemic control must be conducted by group of medical experts from basis of the mechanism of human intelligence, and introduced the medications used in treating COVID-19 in China and globally.

There were reports that patients suddenly died in home and on street. Even if patients cured, the sequelae are terrible. Autopsy shows that lungs of died patients were filled with tiny blood clots, if the large-sized such blood clots fall off into the brain or heart will cause stroke or heart attack.

Currently diagnosis then home-isolation without treatment is in forcing patient into ICU to paralyze medical system. We must help people self-treatment at easy cure-time of just beginning to block the source of epidemic flood by handy diets boosting autoimmune, such as, vinegar, honey and vitamins.

The cure at the time of the onset beginning will massively cure potential patients. In China, at the start of epidemic control, the ratio of suspected cases confirmed as COVID-19 was over 90%, after 4 days of use of Chinese medicine, the ratio dropped to 30%, and with a longer time dropped to 3%.

The good natural cure will not be used due to the misleading of Western medicine, medical experts and people reject empirical cures due to unscientific. TCM was also rejected in its birthplace, only by the enforcement of China’s top leaders, it was able to participate in the treatment of COVID-19.

Now, many hopeful synthetic drugs, such as, Hydroxychloroquine, were tested as ineffective and stopped the use in many countries, but, in China they used as magic cures; because in the west they used them in killing manners, China used them safely combined with other medications as assistants.

The side effects of hydroxychloroquine caused by killing use, the powerful cure achieved in France is from the synergistic effect of smart combining use with azithromycin, thus reduced nasopharyngeal viral-load in 83% negative at Day7, and 93% at Day8; and patients were rapidly discharged from ICU.

The best cure should be from combining medicinals as combo by putting them in half of their normal dosage; the more medicinal combined, the more curative multiplied, the more side effects reduced. If adds some immune boosters will get more curative effect.

Vinegar, honey, vitamins and Chinese medicine can be used as mates for most of drugs.

At the time that humans need the cures for fighting against virus, the effective synthetic medications were tested as ineffective and effective empirical medications were rejected to use by the name of unscientific, such tragedy is not the simple problem of medical philosophy, but the problem relates human nature.

It is inevitable that food is contaminated by viruses. If the virus is brought into the body by the food, and thereby produces antibody, it can avoid causing pneumonia. The effect will be better than that of the virus entering from the nasal cavity. Therefore, covers own mouth and nose is the best protection for avoiding suffering bad consequence.

In China there was a new born baby with antibody on COVID-19 from his mother; which inspired that Canada should lab test to confirm whether food born or skin-touch born COVID-19 can avoid pneumonia and whether thus produced antibody can prevent re-infection. The sampling way for diagnosis also needs to be changed from excrement.

1.. The mechanism of human intelligence and the humanization of epidemic control

In Canada, April 21, 2020, article COVID-19 outbreak at B.C. chicken processing plant; 28 employees tested positive reports that, so far, 28 employees at the chicken processing plant United Poultry Ltd. on East Cordova Street Vancouver have tested positive for novel coronavirus. After one employee tested positive, all 71 staff members tested, an additional 27 positive cases were identified, and the plant was closed.

In United States, Apr. 27 2020, article Tyson Foods chairman warns ‘food supply chain is breaking’ as coronavirus forces plant closures reports that: More than a dozen packing and food processing workers have died after contracting Covid-19. Meatpacking workers often work shoulder to shoulder for hours, increasing their risk of exposure to the virus. Meat processors are closing U.S. facilities after workers test positive for Covid-19, and millions of pounds of meat will disappear from the food supply.

Besides the break of the food supply chain, the virus-contaminated foods will be the channel for virus transmission. Mankind is facing an unprecedented survival crisis; we must control the pandemic as soon as possible, for which, we must fix the problems on the track of pandemic control.

Faced with increasingly death from improper pandemic control, there were more and more people start to criticize their politicians for missing precious time to control the pandemic and resulting in a large number of deaths. As my view, the cause is not only in the personal quality of the politicians, but also, more in the common intellectual flaw of people.

In fact, suppose that those critics take the positions of current politicians, they may not be able to do better also, because they all have inevitable natural shortage in the intelligence as that of we all. Such intellectual flaw covers all people and there is no one able to enjoy the exception. Includes me, the man is in talkative here without sense for self-shaming.

The different results from different countries in pandemic control, such as, China, South Korea and New Zealand, showed the right decision making in epidemic control do can avoid the death of people; which is the reason that caused the anger of the critics in some worse pandemic controlled countries; then, how to realize the perfect decision making.

Now, please look at the mechanism of human intelligence and the flaw in behavior control of people.

People take the IQ scores as an indicator for judging intelligence of a person. The studies show that whether in a same ethnic population or between deferent ethic group, the ratio of IQ level in same population from low to high is distributed in normal curve, which means that there is always people in low-intellectual level, even if the people who were born in the same family may also be difference in IQ scores.

Moreover, the level of the IQ scores cannot guarantee the humanity or inhumanity of person in social behaving, and it cannot guarantee the bad or good of a person contributing to society, even if those scholars that educated by world top elite universities.

Studies show that the terrorists or serial killers were same with normal people in terms of the IQ scores, the brain structure and the executive functioning, besides the poor reasoning on moral cognition; and some of them even have a higher education background, which meant that the dead killers are living among us as normal people in unidentifiable before them making tragedies.

May 26, 2017, in article What science can reveal about the psychological profiles of terrorists, Dr. Coral Dando, the Professor of Psychology, University of Westminster, discussed the psychological basis of the terrorists from the research in imprisoned Columbian paramilitaries, in compared with normal people of non-criminals, the terrorists have no differences in the terms of IQ or executive functioning besides the difference in moral cognition with poor moral reasoning.

Oct. 1, 2017, in Las Vegas, Stephen Paddock fired on a crowd of concert-goers and killed 58 with injured 851, then he took own life. By slice anatomy on his brain, the director of neuropathology at Stanford University Dr. Hannes Vogel who said that “With a good deal of screening, I didn't see anything” that could explain why Mr. Paddock became mass killer. There was no evidence of frontotemporal lobar degeneration, which affects “executive functions,” including decision-making and social interactions, and can cause personality changes and unrestrained behavior.

Most recent in Nova Scotia, Canada, there was a tragedy of 23 people were shot with burnt houses and cars, the killer Gabriel Wortman was a denturist in ran two clinics and has been a wealthy man of own several properties. Some people who are familiar with him said that he was a friendly nice man and was well educated in bachelor's degree. No matter from what point of view, his personal qualities and abilities were far exceeding the average level of people.

Until he kills so many innocents, no one would believe that he was so cruel; no one knew that under his trustable nice feature was inhuman beast nature. Many such tragedies of manmade disasters and MRI brain scans were both proved that it is not all people in human feature are in proper human nature.

MRI brain scan shows that the antisocial behavior of criminals were caused by strikingly smaller of the brain’s region that contribute to emotion perception, empathy and recognizing and caused them cannot produce the feeling of guilt, so that they brutally hurt others without hesitate. The brain of the bullies was abnormal in wrongfully perceiving pleasure from intentionally inflicting pain on others.

Unfortunately, human social environment has also created good conditions for these people to perform evil deeds. Because of in daily life, people grouping in social activities will naturally produce crowd psychologies to distort or kidnap the normal behavior of people, and thus made social governance too complicated.

In the book The Crowd: A Study of the Popular Mind 1895, the writer Gustave Le Bon (1842-1931) claims that there are several characteristics of crowd psychology: "impulsiveness, irritability, incapacity to reason, the absence of judgment of the critical spirit, the exaggeration of sentiments, and others...". “The conscious personality has entirely vanished; will and discernment are lost. All feelings and thoughts are bent in the direction determined by the hypnotiser.”

In the book The Era of Mob, Monsieur Serge Moscovici (1925-2014) said that: In short, the era of mob is a handful of people on the illegal use of a huge crowd in order to achieve the purpose of the interests of small groups face sounding era.

British philosopher and Nobel laureate Bertrand Russell (1872–1970) once said that: “One of the painful things about our time is that those who feel certainty are stupid, and those with any imagination and understanding are filled with doubt and indecision.”

The study of Dunning-Kruger Effect show that low ability people are over self-estimated as superior and capable than others, therefore they are more active socially in fighting for good, but, they can only make bad due to they cannot reasoning for bad consequences; and people grouping produced crowd behaviors will help them to act as opinion leaders and in dominating social governance.

Feb. 09, 2014, in article Management is the Art of Playing Human Nature, I indicates that human behaviors are determined by dual natures: The cultural nature of those acquired altruistic qualities, and animal nature of those inborn selfish instincts. The Management is to finish purposeful tasks with the culture nature driven by meeting the animal nature with payment under the enforcement of regulations.

The free campaigned partisan politics without quality control on candidates has forged a ladder for over self-estimated low ability people to take the power of State Apparatus and thereby is just in magnifying the harm of human animal instinct and crowd behaviors. This is the main cause of the world is increasingly towards inhuman way.

Above are the behaviors of people who are with somewhat abnormal in the intelligence. But for the most of normal people also cannot be perfect performed in social activities and daily life with somewhat shortage in intelligence.

A man who was awarded the Nobel Prize, and was socially titled as philosopher, logician, mathematician, historian, writer, essayist, social critic, political activist; so many titles are the best proof for the versatility of the man. For most people, it is difficult to obtain any of these titles. Only such a wider range learned man can be in perfect reasoning function, and thus what he said will be in highest credibility with fewer mistakes. The man was British Bertrand Russell (1872 – 1970).

As well recognized outstanding versatility, Bertrand Russell was not self-proud but said that “None of our beliefs are quite true; all have at least a penumbra of vagueness and error. The methods of increasing the degree of truth in our beliefs are well known; they consist in hearing all sides, trying to ascertain all the relevant facts, controlling our own bias by discussion with people who have the opposite bias, and cultivating a readiness to discard any hypothesis which has proved inadequate.”

What British Bertrand Russell described phenomenon in human intelligence is from normal healthy people. In fact, the intelligence and behavior of people in human society are far more complicated than this.

However, historically the people of China have recognized and have been in properly preventing such harm, so that developed a civilization that is radically different with that of the West. China is in peace and never positively provoke war, but the west is endlessly provoking wars.

Gavin Menzies, the British submarine lieutenant-commander, as career life, once visited many countries and touched by ancient monuments that left by Zheng He Fleet of China. After retirement, on own spending, he cost 14 years to have researched on Ming treasure Voyages by visiting historic sites of 120 countries and more than 900 libraries, museums and archives. Then accordingly wrote books 1421: The Year China Discovered the World (2002) and 1434: The Year a Magnificent Chinese Fleet Sailed to Italy and Ignited the Renaissance (2008).

In the book, he appreciated the practice of the Zheng He Fleet with 7 times around the world, besides fair trade with the visited countries, did not carry out colonial ruling, no occupying, looting and killing. As my view this was the contribution of 5,000 years civilization of China to have properly cultured quality of the people of China from intelligent basis.

The miracle that computer program AlphaGo beats human top professional game Go player by referencing pre-inputted layouts of past played game Go created demonstration for understanding the work-mechanism of human brain and which will help to understand the comment of the Bertrand Russell.

Dec. 29, 2019, I once wrote article The mechanism of human intelligence and the humanization of social governance, in which I indicate that since 2000 years ago, the successive governments of China took Confucianism as only guidance for regulating social morality by strictly control ignorant ideologies, which cultured high quality people of China with ability of proper self-control on social behavior with highest IQ globally.

In article I also indicate that AlphaGo was developed computer program for playing China’s 2,500 years old board game Go that is designed for two players, in which the aim is to surround more territory than the opponent by abstract strategy, see follow photo, the left one is Go, the right one is chess.

Source of Go: http://tupian.baike.com/a3_56_54_01300000194281121838544482903_jpg.html

Source of chess: http://games.sports.cn/server/guoxiang/2008-04-22/1442015.html

In China, the computer was also called as electronic brain, which is more realistic for understanding AlfaGo in consideration of the role that it acts.

The fact that AlphaGo beats human professional Go player by referencing those pre-inputted layouts of past played game goprovides us an ideal demonstration for understanding the physiological-structure and working-mechanism of human brain by comparison with the well-known assembly-structure and working-principle of the computer.

Actually, our brain is not mysterious at all; it is the acquired knowledge as references in supporting human brain reasoning, judging and decision making.

It is easy understandable that supposes the pre-inputted layouts for AlphaGo is not the game Go but was the chess or any other games, then AlphaGo cannot beat human Go player who is even in primary level.

In comparison with work-mechanism of computer program AlphaGo, human brain is in taking acquired knowledge as references to support reasoning.

It is easy understandable also that people cannot reason something that has no related knowledge in brain.

Because of there are vast differences in the acquired knowledge between people to people, so that the ability in reasoning function is big different among people; which is why “none of our beliefs are quite true; all have at least a penumbra of vagueness and error.

It is easy understandable also that people who learned more and acquired more will be more perfect in reasoning function with more optimized practice in less mistakes. This point is vital important for the people who are occupying the position of the lawmakers of government or the management of business. Because of for them, a slight mistake may cause big loss.

It is easy understandable also that in any ethnic group and in any country, there are always people with different levels of the intelligence. For the better social governance concern, the key lies in the political system can ensure those who have learned more and acquired more useful knowledge are able to engage in the policy making or ministers in the governance.

Similarly, it is easy understandable why that people in democratic countries cannot understand the technocratic democracy of China and the people in the background of western medicine cannot understand TCM in despising it as unscientific, but addicted in their believed scientific way that cannot treat novel coronavorus.

Such a root intelligent shortage has badly affected the epidemic control in China and globally.

Feb. 23, 2020, I once wrote article Some medical experts are in acting as the Killer aid of SARS-CoV-2, due to that they persuade people not use of empirical medicine or folk medications on the pretext that the empirical ones may be harmful because they are unscientific.

Above findings revealed secret why that the social governance of China has been the best since ancient time, with the Old and New Silk Road to provide life necessaries globally, and now, after basically contained epidemic, China is in resuming social life as normal as before. This derived from the unique civilization – quality citizens and quality government in democracy by group of selected high quality people.

Since 771 to 221 BC, China once suffered 550 years chaos of wars between over 100 vassal states as that of the Dark Ages in the Europe. The chaotic social environment promoted enlightenment and laid the foundation of China’s civilization. The most important enlightenment was the understanding for the vital reality – it is not all people in human feature are in proper human nature, some are in defective reasoning function in taking wrong as right and taking stupid as smart.

Since then, China has been culturing people by Confucianism as only conducting on social morality while suppressing other ignorant ideologies and the social governance has been in technocratic democracy by selecting (imperial examination) group of high quality learned people who know how.

In the book Asian values and the United States: how much conflict? 1994, David Hitchcock introduced a survey on the societal values that demonstrated the contribution of culturing people by Confucianism:

Asian respondents are: (i) orderly society; (ii) societal harmony; (iii) accountability of public officials; (iv) open to new ideas; (v) freedom of expression; (vi) respect for authority.

American respondents are: (i) freedom of expression; (ii) personal freedom; (iii) rights of the individual; (iv) open debate; (v) thinking for oneself; (vi) accountability of public officials.

Different preferred values stemmed from different civilization to have caused people different in social behaving. Asian people cultured by the culture of pursuing social order and harmony of China in tending to collectivism with concerning for protecting the collective interests, while Western people cultured by the culture of looting and killing of the dark Ages in tending to Individualism with protecting the individual interests.

The low mortality rate in Covid-19 in Asian countries is due to the high quality of people in self-discipline and well cooperation with government. But in western countries, there more people are just going on opposite without self-discipline on social order in free practicing according to own preferred accord, so that pandemic can never be controlled.

The rationality of Confucianism and the practice of technocratic democracy of China once attracted missionaries from Europe to China; they wrote it back to Europe, and were appreciated by the European enlightenment thinkers; they asked that why China is so peaceful, but we are constantly killing of each other.

The people of China not only respect learned people of China, but also respect foreigners.

There were reports that since ancient time, there were foreigners working as officials in the government of China. The famous one was from Britain.

In the Qing Chinese government, British diplomat Sir Robert Hart (1835 – 1911) was serving as the second Inspector-General of China's Imperial Maritime Custom Service from 1863 to 1911. Beginning as a student interpreter in the consular service, he arrived in China at the age of 19 and resided there for 54 years. At this period, Sir Robert Hart hired hundreds Britons working as officials of the government of China.

Nowadays, the lawmakers of China are all noted scholars and entrepreneurs.

In this time epidemic control, The top leaders of China authorized a team of medical experts who know how as leader, the officials in all level governments are only work as assistants to perform their plan and later replaced the team leader of medical experts, because that the leader opposed the use of TCM, thereby massively cured patients by the treatment of combination of all available therapies.

Indeed, the reason of the replacement of the team leader of medical experts was not in the problem in the personal quality but in the problem of his acquired knowledge in western medicine (WM). The reference in WM cannot support the reasoning function for understanding the experience based TCM, but deadly addicted in scientific way to insist looking for killing.

This is also same in western countries, this is why that some medical experts reject the use of experience based therapies by the pretext of unscientific and the politicians have been wrongfully convincing people that wearing mask cannot prevent from infection for the concern personally, without reasoning function for that only covering mouth and nose can effectively stop the spread of the virus by confining the virus in the body of the individual for the concern publically.

There articles from great many countries are reflecting on that how their politicians have ignored the rational advices of their medical experts to have missed the opportunity for saving lives by effectively epidemic control.

The increasingly death of people from the virus revealed the fact, for the concern of saving lives, the politicians must turn over the right for conducting epidemic control to the team of medical experts who know how, and the politicians themselves work as assistants to fully support the work of the team as the politicians of China has been in doing.

Also, as my view, existing pharmaceutical regulations and medical regulatory agencies in all countries are no longer able to adapt to quick respond to the epidemic control, so that all medical regulations and medical regulatory agencies should turn to co-work with the team of medical experts according to ongoing epidemic situation, and turn to discuss feasible regulation together.

The outdated medical regulations have been in making disaster. Such as, in this time epidemic control, China’s medical experts brought medicinal preparations of TCM to add Italy, but it was not allowed to use for saving life due to the restriction of the policies. Because of has no effective cure, in Italy, people are in massively killing, but the life-saver did not allow to use, which is typical manmade disaster.

In China, it also happened that private doctors who cured patients by experience based therapies, but were penalized by the Regulatory Authority. The one cured patients by injection of medical disinfectant Phenol in the small dose, and other cured patients by TCM. But the punishments were cancelled after public criticism that any effective treatment should be allowed clinical use during the epidemic period.

The root cause of such manmade disaster derived from improper social governance. As same as the bad role of improper Medical Regulatory, as the executive of the State Apparatus, some politicians are also playing negative role. The smart politician should have understood that any improper comment may negatively affect the national practice in epidemic control and may cause massive deaths of people.

The improper speeches of the politicians based on the kindhearted and enthusiasm or by consulting some medical individuals may cause more death and thus accumulates unforgivable bad records and finally causes unaffordable bad consequences for themselves, and the grief of people who lost beloved ones may be in accumulating the hatred energy towards them.

The epidemic control involves a large number of people in live or death, and any administrative error will make more people lost life. It is inevitable that the politicians or regulatory officials who made error by improper speech or actions will be liquidated after them stepping down from the rolling position soon or later.

Politician should understand that the right for epidemic control is a time-bomb that has tied on their body; their improper speech is the trigger bottom, because of as politician in the rolling position, any of their speech or action in full-hearted for good may play a negative role to badly affect the epidemic control and cause massive death.

The smart politician should turn to fully support the work of the team of the medical experts who know how and to reduce oneself showing up and speaking out as less as possible, this is the best way for reducing mistakes and trouble for their own and the people of their countries.

It is not the virus, but it is the questionable civilization in kidnapping people to be killed.

1.. The methods of China in treating COVID-19

At the start, the treatments are fully in western medicine, such as, antibiotics, hormones, nutritional support, etc., with large amount of death from ICU rescue. Later, the experts in TCM appealed for joining the treatment by the way of TCM integrates western medicine, and were adopted by the enforcement of the central government with a special meeting.

1.1.. The cause of the death

It said that, at the final time of the life, a patient wrote a note: I am willingly donating my body to my country and where my wife is? (Every time revise to here, I am tearful); thus, gradually got bodies for anatomy to investigate the cause of the death.

1.1.1.. The autopsy showed that a large amount of mucus blocked the bronchial airway inside the lungs, and then asphyxia caused the death of patients, which means that the process of death is extremely painful to be suffocated soberly.

1.1.2.. It has also been reported that patients suddenly died from the hopeful good condition; presumably it was due to immune system self-destruction from cytokine storm, thereby cause death from multiple organ dysfunction or failure.

1.2.. The hardship of Chinese medicine was able to be clinically used

This issue related to the right treatment of COVID-19 patients in Canada, I have to discuss in a little talkative.

In China, the conduction of epidemic control was under the senior medical expert team of renowned medical experts and the officials in all level governments work as assistants to support to carry out the plans of medical expert team.

Feb. 23, 2020, I once wrote article Some medical experts are in acting as the Killer aid of SARS-CoV-2, due to that they persuade people not use of experience base medications on the pretext of unscientific; which was same in China.

Mar. 12, 2020, a Mandarin article of The specialist was quietly replaced from the position of team leader of medical experts group introduced the process of the formation of senior medical expert team of the National Health and Medical Commission of China.

On Jan. 19, a respiratory specialist who was appointed as the team leader of the senior medical expert group to responsible for conducting the treatment of COVID-19 patients; because of experts in the team were all in the background of western medicine, so that they resist the participation of the medical experts in TCM for the treatment of Covid-19.

On Jan. 25, the top leasers of China held a meeting and decided the strategy of Chinese medicine integrates Western medicine to treat COVID-19 patients. On the same day, the first national team in Chinese medicine arrived in Wuhan, China.

On Feb. 8, the senior medical expert group was reorganized and some experts in Chinese medicine have been added to the medical expert team; and the respiratory specialist was quietly removed from the position of team leader, but he remained as the member of the medical expert group.

The article indicated that the respiratory specialist who made a directional error in the treatment of patients in COVID-19, due to he still insisted to use that he invented treatment by large amount of antibiotics and hormones, which have been proved to be wrong during the treatment of 2003 SARS.

The article alleges that the respiratory specialist has been resisting against the experts in Chinese medicine and said that he did not expect Chinese medicine to have a strong antiviral effect.

In other report, the respiratory specialist said that if use Chinese medicine, it must be with proved ability in killing virus, prevent the virus from entering cells, and prevent immune cells from self-injuring due to overreaction.

The practice of the respiratory specialist proved that what I said above, the people cannot reason something that has no related knowledge in brain. With the knowledge of western medicine, he has been always thinking about how to kill virus.

TCM is never thinking about how to brutally killing but how to peacefully restoring. This is also the philosophy of China and is the reason that China was no conquest but built Great Wall as defense.

As my view this was the contribution of 5,000 years civilization of China.

Now, Faced with viral challenges, the performance of Western democracies has exposed the inherent flaws of civilization. Medicine is an important part of human civilization. A civilization with inborn defects cannot produce humanized medicine.

2.3.. The cognition of the effectiveness of Tradition Chinese Medicine

The process that proved Chinese medicine effective was from the treatment of 2003 SARS.

Deng Tietao (1916 – 2019) was a professor in TCM and doctoral advisor at Guangzhou University of Chinese Medicine, once named as the Master of National Medicine.

In 2003, the nurse Deng Qiuying who contracted with atypical pneumonia, in 3 days, she was in high fever, low white blood cells and platelets, and a large area of infection on the lung lobes, was in almost dying. Her husband Zou Xu who is the deputy director of Guangdong Provincial Hospital of Traditional Chinese Medicine asked his PHD tutor Deng Tietao for helping.

Deng advised that the use of antibiotics and hormones must be stopped immediately and turn to the treatment by pure Chinese medicine. Zou Xu ordered to treat his wife by pure Chinese medicine under the suspicious of the doctors who were in charge of the treatment, Six days later, Deng Qiuying's fever subsided, and soon recovered without any sequelae.

The success made Deng Tietao was appointed as the team leader of the TCM expert group to treat 2003 SARS patients. At the time, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine received 73 SARS patients and achieved zero death of patients, zero infection of medical staff and cured patients had no sequelae.

The SARS patients who treated by large amount of antibiotics and hormones were not only death but also had sequelae of the necrosis of the femoral head, and fibrosis of the lungs, the cured patients have been in fighting against the sequelae with a poor quality of life in past 17 years; which was that “proved to be wrong during the treatment of 2003 SARS.”

It said that Professor Deng Tietao once several times saved TCM by suggesting to central government .

Firstly, he suggested the establishment of the State Administration of TCM.

Secondly, he stopped the cancellation of State Administration of TCM.

Thirdly, he stopped the universities of TCM to be merged into the one of Western medicine.

Fourthly, he reiterated that TCM cannot be lost, and calling on the whole society to attach importance to it.

Fifthly, he suggested that TCM intervenes in the treatment of 2003 SARS.

2.4.. It was that Chinese medicine essentially contained epidemic of the COVID-19

From Jan. 22, 2020 to Mar. 4, 2020, the senior medical expert group has totally updated 7 version of conduction in the treatment of COVID-19 and gradually increased the use of TCM, now has formed several standard formula.

Recently, in China, patients in COVID-19 are being massively cured and new morbidity is declining, and the daily life of people and production of enterprises are gradually returning normal, which brings the confidence to the people world widely.

As long as we take right protection and treatment, the coronavirus can be defeated.

The promising achievement is stemmed from the massive use of integrated treatment of Chinese Medicine combining with western medicine in quickly curing patients.

Mar. 3, 2020, article What role does Chinese medicine play in the prevention and control of the epidemic? This is a set of data said that in the medical staff supporting Wuhan came across the country, there nearly 5,000 were in TCM, and the treatment participation rate of TCM in Hubei province was 91.05%. In other regions were 96.37%.

The good treatment of Chinese Medicine did not use on all cases, I think that should thank the great contribution the philosophy of western medicine, it harmed famous Specialist, so that he resisted use of TCM and has caused more death.

It is the acquired knowledge in determine the outcomes of people in reasoning, judging and decision making. The irrational knowledge support irrational reasoning with irrational practice and bad result, the rational knowledge support rational reasoning with a rational practice and good result.

Wuchang District has the worst epidemic in Wuhan city. On Jan. 28, the proportion of suspected cases confirmed as COVID-19 was as high as 90%. On Feb. 2, Chinese medicinals were used among the people were in centralized isolation, after 4 days by Feb. 6, the diagnosed rate had dropped under 30%, and by Mar. 5, it was only 3%.

The patients who diagnosed as negative, their lymphocyte count, and white blood cell count have increased, which meant that the patients have really recovered.

The facts have clearly showed the magic curative effect of Chinese mecinals.

The clinical cases suggest that TCM prevents mild patients from developing into critical ill. In the treatment of severe and critically ill patients, Chinese medicine has also reduced fever, promoted exudation and absorption, increased oxygenation levels, and reduced pulmonary fibrosis. It should be said that Chinese medicine integrating Western medicine effectively reduced the mortality rate.

In the treatment of COVID-19 patients, Chinese medicinals avoided mild ill patient developed as critical ill, thus avoided the use of ICU that is not only heavy economical and medical burden, but also 50% death from asphyxia and the main cause of medical staff being infected.

Mar. 25, 2020, I Googled and got a article (It said UPDATEDUPDATED 1 DAY AGO, without exact date available, many reports went such way, the irrational is easily popular than rational), it said that “In Italy, there are 24 Italian health care workers who have died during the coronavirus pandemic” “Almost 5,000 health care workers on the frontline of Italy's COVID-19 crisis have contracted the coronavirus.”

The use of Chinese medicinals will largely reduce such tragedy.

Below is the translation-reedited fromm March 19, 2020 Mandarin article what role does Chinese medicine play in the prevention and treatment of novel coronavirus pneumonia?

http://www.satcm.gov.cn/hudongjiaoliu/guanfangweixin/2020-03-19/14061.html

The writer is Zhang Boli, Academician of the Chinese Academy of Engineering, President of Tianjin University of Traditional Chinese Medicine, Honorary Dean of the Chinese Academy of Chinese Medical Sciences, and the member of the senior expert group of the epidemic prevention.

Also, Zhang Boli was one of jointly appealed that Chinese medicine participates in the treatment of the COVID-19 patients and approved by a special meeting of the central government.

At earlier time, many patients were not diagnosed. Based on past experience, all of them gave Chinese medicine at first, whether it is common cold, flu, or new coronary pneumonia, Chinese medicine has a certain effect, thereby stabilize the emotions of the patents. After a day or two, the fever will subsided and thus will give patients confidence.

In total 13 districts and counties of Wuhan City, 3,000 copies of Chinese medicines were issued on the first day of starting isolation, and 10,000 copies in next day ... 400,000 copies have been issued so far.

On February 14, there 209 TCM experts were full charge of a temporary hospital for comprehensive treatment with traditional Chinese medicine. The antipyretic time and healing time of the patients were significantly shortened, and the ratio of mild developed as severe cases was significantly reduced. At the same time, the neutrophil count and lymphocyte count of the patients were significantly increased.

After gained experience, almost 10,000 patients in more than a dozen temporary hospitals were start to use traditional Chinese medicine, with a coverage rate of 95%.

Since February 14 to March 10, in TCM experts fully charged temporary hospital, a total of 564 patients have been admitted, and 392 patients have been cured and discharged, and some patients have been transferred to other hospitals. None of the patients had become critically ill, and the medical staff had zero infections.

The adjuvant treatment for acute patients is also effective. For acute ill and critically ill patients, respiratory support, circulatory support, and life support are essential. Traditional Chinese medicine can also play a supporting role as assistance.

Some patients have lower oxygenation levels and fluctuation in blood oxygen saturation. In this case, using Chinese medicine injection as soon as possible and taking herbal decoction, the patient's blood oxygen saturation will be stable after one or two days, and the oxygenation level will go up after another day or two.

Some patients use ventilator, abdominal fullness and constipation affect the effect of oxygen therapy. At this time, using some traditional Chinese medicine, the stool will be drained and the abdominal fullness will be eliminated, the effect of oxygen therapy will be significantly improved.

Some Chinese medicine have significant effect on controlling the inflammatory response syndrome to reduce that inflammatory factor storms and aggravating inflammatory response,

Some patients have poorly controlled lung infections or slow in absorption. Adding traditional Chinese medicine injections can work synergistically with antibiotics, and many patients are cured in this way. Now many hospitals in Wuhan have also started to diagnose for severe patients by Chinese medicine combined with western medicine, and more patients have used the integrated treatment of Chinese medicine and western medicine.

For the patients in recovery period, traditional Chinese medicine can promote the progress and reduce the sequelae. Although some patients are recovering, the nucleic acid test of the virus has turned negative also, but the symptoms such as fatigue, cough, and poor mental status are still in existing, especially the patients' lung recovery status and clinical symptoms are not symmetrical and not synchronized.

Though the patient was discharged, but there was still unabsorbed inflammation in the lungs. In this case, traditional Chinese medicine can improve the symptoms of patients during rehabilitation, at the same time can promote the absorption of pulmonary inflammation, reduce adhesions, promote the complete repair of damaged organ tissues, and improve immune function.

Basic research has been performed on a compound traditional Chinese medicine that proved clear clinical effect.

The research by network pharmacology found 286 key targets and 21 pathways regulated by the main chemical components, including 28 genes related to respiratory virus infection, 68 interleukins genes related cytokine activation and 17 genes related to lung injury. The compound has the role of avoiding or alleviating cytokine storms, multi-target protection on lungs and other organs.

2.5.. Chinese medicine will largely reduce fatal consequences

March 27, 2020, article COVID-19 linked to cardiac injury, worse outcomes for patients with heart conditions said that, “COVID-19 can have fatal consequences for people with underlying cardiovascular disease and cause cardiac injury even in patients without underlying heart conditions, according to a review published today in JAMA Cardiology by experts at The University of Texas Health Science Center at Houston.”

There were reports that Novel Coronavirus can have fatal consequences of the fibrosis of the lungs in 20% to 30% of impaired lung function. Japanese pathological studies report that patients even got brain infection.

Chinese medicine can repair injured body to mitigate the harm caused by the virus to avoid sequelae.

2.6.. A COVId-19 infected Chinese lady cured by TCM in France

Ms. Li Li has lived in France for more than 30 years. She found French-Chinese Friendship Association. Entrusted by the Paris city government, she organizes extracurricular interest classes in dozens of public elementary schools to teach Mandarin and Chinese culture, and warm welcomed by students, parents and city government.

In March 2020, Ms. Li Li contracted Novel Coronary Pneumonia with a headache, a sore throat, a dry throat, and a low fever like a cold. After three days, she lost his sense of smell and taste; his chest felt a sense of pressure; breath inhalation was difficult and short. The number of breathing increases; it is not like a bad cold, it will make people feel uncomfortable at once; but COVID-19 slowly invades slowly. Lasting more than a week, some people can even drag it to two weeks.

Some young people feel headaches and fever a small problems, but they enter the intensive care unit in about ten days later.

By the seventh or eighth days, it was hard to endure, headache, sore muscles, diarrhea. Family doctors use Doliprane to cool down and adds vitamin C. A friend found the best doctor of Chinese medicine in Europe and prescribed a prescription for her and a Spanish lady who has a fever of over 40 degrees and has been lasting for a month.

The doctor asked her to boil orange peel to drink. The white bars between the orange skins can reduce the phlegm. A combination of total 19 kinds of Chinese medicinals purchased and water boiled to drink three times daily. In two days later, the sense of taste and smell came back. Because the high fever continued to 39 degrees, she was hospitalized.

The treatment in Hospital is oxygen inhalation, intravenous infusion of glucose saline plus an antibiotic, and oral administration of an antibiotic. Doctors and nurses checked every four hours. Measurement items include blood oxygen, breathing, heartbeat, blood pressure, etc.; blood tests performed every day to detect various indicators. Did an electrocardiogram and routine examination of the whole body; dod a COVID nasal mucosa test, which is positive twice.

Finally, the fever was gone and did not need oxygen. She obviously felt "alive" and asked curiously what medicine the doctor used, so magical and effective? The doctor replied that this is not a credit for medicine, but a credit for your own body's immune system.

After 7 days of in-patient treatment, the condition of Ms. Li Li soon improved, and she was discharged in March 29, and returned home for isolation and rest.

2.7.. A research shows that a preparations in pure TCM is effective on COVID-19

Mar. 20, 2020, Pharmacol Res published article Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2) reported a pure preparation in TCM showed effective against SARS-CoV-2.

The composition of the preparation: Forsythia, Honeysuckle, Ephedra, Almond, Gypsum, Iisatis root, Male fern rhizome, Houttuynia cordata, Patchouli, Rhubarb, Rhodiola rosea, Menthol, Licorice. The starch is auxiliary material.

Abstract

Purpose

Lianhuaqingwen (LH) as traditional Chinese medicine (TCM) formula has been used to treat influenza and exerted broad-spectrum antiviral effects on a series of influenza viruses and immune regulatory effects [1]. The goal of this study is to demonstrate the antiviral activity of LH against the novel SARS-CoV-2 virus and its potential effect in regulating host immune response.

Methods

The antiviral activity of LH against SARS-CoV-2 was assessed in Vero E6 cells using CPE and plaque reduction assay. The effect of LH on virion morphology was visualized under transmission electron microscope. Pro-inflammatory cytokine expression levels upon SARS-CoV-2 infection in Huh-7 cells were measured by real-time quantitative PCR assays.

Results

LH significantly inhibited SARS-CoV-2 replication in Vero E6 cells and markedly reduced pro-inflammatory cytokines (TNF-α, IL-6, CCL-2/MCP-1 and CXCL-10/IP-10) production at the mRNA levels. Furthermore, LH treatment resulted in abnormal particle morphology of virion in cells.

Conclusions

LH significantly inhibits the SARS-COV-2 replication, affects virus morphology and exerts anti-inflammatory activity in vitro. These findings indicate that LH protects against the virus attack, making its use a novel strategy for controlling the COVID-19 disease.

2.. Philosophy decides that western medicine fails but TCM magic cures COVID-19

2.1.. Why western medicine failure in saving life from COVID-19

Historically, the antibiotic penicillin and vaccinia vaccination once saved lives of great many people; today we even can make life by genetic technology in a tube. So public have been convinced that Western Medicine (WM) is most advanced, most scientific and most reliable. Even more, in 2005, we once cheered for the completion of Human Genome Project with the happy of getting a new powerful therapeutic approach.

People thought that the understanding of the human genome was equivalent to have controlled the code of life, and then we could uproot all diseases by simply adjusting the password of life. However, until to today of 15 years later, it seems have no genetic therapies been applicable clinically; why? Because of there may be dozens even hundreds different gene-fragments in affecting the development of one diseases.

Therefore, those believed as most advanced, most scientific, most reliable genetic therapies are only hopeful flowers that may need long time, and more study to bear enjoyable fruits. But, I firmly believed that, this fruit can never mature forever.

Today, in faced with large numbers of death under the 2019 novel coronavirus, western Medicine seems lost its trustable solemnity in helpless viewing increasingly people being killed, why?

The long-term abuse of antibiotics has domesticated bacteria and viruses; they are able to rapidly mutate to fight against the new version of drugs, and therefore they have been adaptively evolution as more and more complicated and difficult to deal with.

There were no suitable synthetic drugs for some diseases, such as, super bugs. Even, those existing drugs were not all safe; the side effects of some of them are becoming new life-threats.

The sadness derived from the improper medical guidance of philosophy.

Due to the mutation of the pathogens is too rapid to be adapted by the way in disease treatment of WM. The cause for such a disappointment, as my view, it is that the guidance of Reductionism ignored the decisive role of human autoimmunity and psychological factors in the development of diseases.

Human body is a complex system that various organs are closely interconnected with interdependent and interacting, there may be many unpredictable factors in affecting the development of diseases, especially the psychological factors.

January 8, 2008, a research crossing the disciplines of psychology, medicine, neuroscience, and genetics reports that Stress Causes Everything: “Stress, to put it bluntly, is bad for you. It can kill you, in fact. A study reveals that stress causes deterioration in everything from your gums to your heart and can make you more susceptible to everything from the common cold to cancer.”

The stress is a disease inducement that is uncontrollable, because it comes from natural or social factors that no one can control, such as, in current moment, the stress comes from the panic of the pandemic of the virus. Someone may not care about in less stress causing, and someone may fear to die with heavy stress.

Many objective facts have proven that the medical route under the guidance of Reductionism is not sustainable feasibly.

While scientific synthetic drug failed in disease treatment, the vitamins and human autoimmune showed magic effect in the treatment of thorny diseases.

The researchers in Cedars-Sinai Medical Center, the Linus Pauling Institute at Oregon State University and other research centers by the test on mice and human blood, they found high doses of the vitamin B3 increased the ability of immune cells to kill the bacteria by 1,000 times.

The researchers in Melbourne University found that a COVID-19 patient recovered from drowsiness, sore throat; dry cough and fever after naturally emergence of several kinds of immune cells in blood as same as that of general flu, which revealed that boosting autoimmune is effective treatment.

Actemra, an anti-cytokine storm drug saved life in COVID19: Dr. Padgett contracted with COVID19 supported by ventilator, his lungs, kidneys and heart started failing with a day or so to live. Doctors saved him by Actemra that is a drug used for treating cytokine storm phenomenon and is testing in China.

The drug Actemra cured Dr. Padgett proved that cytokine storm is one of the reasons that cause COVID-19 patients death. The case also proved that enhancing autoimmunity at the vital time that immune cells nearly failure in fighting against virus by timely providing armors to protect them; which is one of the effective treatments for COVID-19.

Apr.16, 2020, article Mum given hours to live after coronavirus infection survives after being turned onto her stomach in ‘proning’ technique said that Stacey Fresco admitted to hospital with Covid-19 on March 20 and hooked up to a life-support machine and unconscious in the ICU at Whipps Cross Hospital in East London. Stacey also had type 2 diabetes and her kidneys and heart were not working properly.

The doctor tried a technique called "proning", where the Stacey was placed on their stomach for 12 hours, thereby helps her lungs transfer oxygen into the bloodstream more efficiently; which made Stacey recovered and the tubes were gradually removed from her body, and after 20 days discharged in April 9, 2020.

Many findings firmly showed that for saving the life of COVID-19 patients, the killing-virus is not essential. It is not the manmade virus killer or vaccine, but any methods that can improve the physical condition of patients will be effective.

Therefore, those, who dogmatically looking for virus killer and convincing people to reject the use of experience-based therapies by the pretext of unscientific is evil manner actually in assisting virus killing people.

Among all methods, boosting autoimmune is the best with much easier in home handy. We must turn to autoimmune boosting from the uselessly wasting time in endlessly failure from looking synthetic drug for killing virus.

Suppose that we can update out philosophical view from looking for killing to be promoting our auto immune, then the available treatments will be plenty and in home handy.

2.2.. Why Traditional Chinese Medicine is powerful in curing COVID 19

Traditional Chinese medicine (TCM) are just good at enhancing human immune system and even the needles of the acupuncture are in playing its curative role by boosting autoimmune, and in this time contained epidemic quickly in China, TCM played decisive role by cured patents massively.

Feb. 15, 2020, a Mandarin article Subversion: Who said that Chinese medicine can't save critical illness? you are wrong report that:

In Feb. 15th, 2020, at the Hankou Hospital of Wuhan city China, an acute patient in novel coronavirus pneumonia developed into critical state of irritability, difficulty in breathing. The expert at the Guangdong Provincial Hospital of Traditional Chinese Medicine, Professor Zou Xu who immediately treats patient by acupuncture needles on four acupoints, after 10 minutes, the patient's vital signs gradually stabilized.

The doctors in western medicine, who participated in the process of rescue, said that if it is not seeing with own eyes, they would never believe that it is true and being convinced the magic curative effect of Chinese medicine. It is sadness that the doctor of Chinese people did not understand TCM, which showed the power of poisonous of so called scientific of the western medicine.

Obviously, the needles of acupuncture cannot kill novel coronavirus at all, then where the magic of their curative effects come from. For this concern, in Mar. 15, 2020, I Googled by the key words: acupuncture, immune; it returned about 9,950,000 results (0.50 seconds) and shocked by the magic curative effect.

2014, Acupuncture modulates the neuro–endocrine–immune network

2014, Acupuncture on Leucopenia, Neutropenia, NK, and B Cells in Cancer Patients

2007, Effect of acupuncture treatment on the immune function impairment found in anxious women.

If Google, you will find a lot of therapeutic function of acupuncture on wide range of diseases that western medicine has been helpless in the treatment.

Just such a reason, in fighting against 2003 SARS and now in fighting against COVID-19 pneumonia, Chinese medicinals are both played key role in curing patients.

The magic curative derived from the rational medical guidance of philosophy.

TCM takes Daoism as guidance in viewing human body as organic wholes with all parts are interconnected and interacted and the psychological factors in playing decisive role in the development of disease; with a thousand years believing that disease treatment is seven tenth in psychotherapy and only three tenth in medication. Its correctness proved by modern double-blinded-placebo cured rate 50-60% and many self-recovered incurable cases.

TCM has never considered the ideas of modern anatomy, virology and etiology, but with a long believing that the well-balanced body will form an effective self-defense system that can resist diseases. Therefore, the treatments of TCM do not directly target on the killing of pathogens, but restores the natural balance of body. Subjectively view, the treatment is focusing on the restoration of natural balance, but the objective effect is in enhancing body's autoimmunity.

Under the guidance of holistic philosophy Daoism, TCM has developed many natural therapeutic methods, and identified about 11,146 medicinal plants, 1581 medicinal animals and 80 medicinal minerals as clinical use and developed nearly 100 thousands of experience-based formulas, which covering almost all known diseases, through long time trial and error clinically.

Modern biochemical and pharmacological researches proved that Chinese medicinals are sorted scientifically according to the therapeutic effect. For example, those are sorted as enhancing digestion are rich in Ca, Zn and Fe, and those as enhancing male sexual ability are rich in Mn and Cu. The bioactive constituents have the therapeutic effect that is similar to that of synthetic ones in killing the pathogens directly and the nutritional effect that is similar to that of orthomolecular medicine.

Some of Chinese medicines can improve human immunity, such as, boosting the weight gains of immune organs, increasing the number and activity of the phagocytes, NK cells and so on. Therefore, in subjective viewing, the treatment of TCM is to regulate the physical balance, but in objective practice, the process of the regulations were in improving immune function, and thereby kills pathogens by strengthened defense system.

In comparison, the practice of modern anatomy, virology and etiology sounds perfect reasonable and scientific, but, this time failure in the battle with COVID-19 demonstrated the sad reality that perfect scientific play has made a simple matter into much complicated.

For the treatment of COVID-19 patients, we must update philosophy from Reductionism of western medicine to Daoism of TCM, from looking for killing to be autoimmune boosting.

The recovered cases demonstrate that for rescuing of COVID-19 patients, the key is not at developing new version of drug or manufacturing ventilators, but at curing patients massively by allowing handy experience based medications to be used and we must give up the dogma that medication must be proved clinically with single or pure composition; such a scientific thought has been badly affecting the use of effective cures.

Such as, the sadness that Italy did not allow the use of medicinal preparations of TCM once happened in China also, it is not from policies, but from some individual medical expert who has deadly opposed the use of TCM by questioning the scientific proof in the pharmacological function for killing virus, for preventing virus into cells, and the effect in reducing self-injury of immune cells from cytokine storm phenomenon.

The old TCM and modern studies were both showing that the best medication is not at developing brand new, but at flexibly use of the existing one. It is not costly purified as single, but easily messed as mixture by combining all available medicinals together to be used as combo. The more medicinals combined, the more curative effect will be multiply-increased, and the more side effects will be multiply-reduced.

On April 3, 2020, the Brookings John L. Thornton China Center convened a webinar featuring experts from Asia to introduce what has worked to combat this pandemic. The below link was China’s doctor introduced the practice of China in massively cured patients by combining use of all available medications, especially the TCM. https://v.163.com/static/1/VK8E016SJ.html

But the speaker was still question about the efficacy of TCM in ignoring the facts that pure TCM has massively cured patients in Wuhan and that only cured patients were the true evidence, which shows that he was a typical victim of the harm of western medicine; and the most of western doctors will be in the same stand to refuse the use of TCM and experience based medication, which was what happened in Italy. This is the reason that I wrote this article and so talkative.

For avoiding the tragedy repeating in Canada; I wrote this article. The facts showed that the bad enemy for containing the epidemic is just those so called medical experts in western medicine, actually they are in playing the role as killer assistants of virus by intention of full hearted for good, because their brain has been poisoned in abnormal by their addicted so called scientific of the western medicine, many of them have lost normal reasoning function.

The reason that we cannot develop treatment for rescuing patients in COVID-19 was that those medical experts in western medicine have been misleading on wrong direction; they addicted in looking for miracle synthetic drug or vaccine, while the ready effective handy medications have been dumped away by them with the indisputable pretext of unscientific.

The so called scientific double blinded clinical trial by developing synthetic chemicals is not only wrong in the practice, but also it is questionable in the nature of humanity because it cheats patients by placebo when dealing with the vital matter of live or die of a people.

We must stop the ignorant play of ideological arguments in scientific or unscientific, but immediately put use of any available medication that can cure patients in any kind of infections by boosting autoimmunity, without the need of diagnosis, so that infected people can be rescued quickly; especially surely avoid our medical staff in Canada from death as that of those in Italy and Spain.

For the concern of handy available for most people, I suggest below remedy:

Daily 4 - 5 times 10 - 20 ml 5% vinegar adds 20 ml honey dilutes by 500 ml water drink (or outside smears water diluted vinegar to be absorbed through the skin, which will take effect more quickly), and 3 grams vitamin C in 6 times daily.

Above remedy will be effective in similar as that of Chinese medicinals, because that they all have property in boosting autoimmune. The effect of honey and vitamin C is easy understandable, here I introduce vinegar.

April 11, 2001, research report The effect of cider vinegar on some nutritional and physiological parameters in mice said that the hemoglobin (Hb), total erythrocyte counts (TEC) and total leukocyte counts (TLC) were raised in all vinegar treated groups.

2018 Jan 29, research report Apple cider vinegar can help clear bacteria and yeast infections; a natural cure said that vinegar could potentially protect the body from harmful bacteria by stopping the growth of bad bacteria and fungus in its tracks, stopping the spread of these infections by destroying their cell walls, protein structure, nuclear proteins, metabolic enzymes altering their structure of the pathogenic organisms.

For critical patients, the intravenous mega-dose of vitamin C in 1–1.5 grams/per kilo weight may be the rescue; and combined with vitamin D and B3 will be helpful also.

The integrating use of nutrient supplements, daily diets and Chinese Medicine will be able to help to quickly empty overcrowded hospitals of Canada by curing patients massively. The thorny diseases, such as, Alzheimer's and Schizophrenia will be cured by Chinese medicine as easy as that of the treatment of seasonal flu.

3.. The feasible approaches for the development of effective medication

It is not costly purified as single but easily mixed as mess by combining all available medicinals together as combo.

The more medicinals combined, the more curative effect will be multiply-increased, and the more side effects will be in multiply-reduced.

It is not develop new, but flexibly use of current available. Focus on boosting autoimmunity by combining current available medications as combo in both of synthetic and natural.

3.1.. The more medicinals integrated, the more effective in therapeutic and the more less in side effects.

3.1.1.. Cocktail therapy Successfully cured patients in COVID-19

March 30, 2020, A Report on Successful Treatment of Coronavirus

To all medical professionals around the world:

My name is Dr. Zev Zelenko and I practice medicine in Monroe, NY. For the last 16 years, I have cared for approximately 75% of the adult population of Kiryas Joel, which is a very close knit community of approximately 35,000 people in which the infection spread rapidly and unchecked prior to the imposition of social distancing.

As of today my team has tested approximately 200 people from this community for Covid-19, and 65% of the results have been positive. If extrapolated to the entire community, that means more than 20,000 people are infected at the present time. Of this group, I estimate that there are 1500 patients who are in the high-risk category (i.e. >60, immunocompromised, comorbidities, etc).

Given the urgency of the situation, I developed the following treatment protocol in the pre-hospital setting and have seen only positive results:

1. Any patient with shortness of breath regardless of age is treated.

2. Any patient in the high-risk category even with just mild symptoms is treated.

3. Young, healthy and low risk patients even with symptoms are not treated (unless their circumstances change and they fall into category 1 or 2).

My out-patient treatment regimen is as follows:

1. Hydroxychloroquine 200mg twice a day for 5 days

2. Azithromycin 500mg once a day for 5 days

3. Zinc sulfate 220mg once a day for 5 days

The rationale for my treatment plan is as follows. I combined the data available from China and South Korea with the recent study published from France (sites available on request). We know that hydroxychloroquine helps Zinc enter the cell. We know that Zinc slows viral replication within the cell. Regarding the use of azithromycin, I postulate it prevents secondary bacterial infections. These three drugs are well known and usually well tolerated, hence the risk to the patient is low.

Since last Thursday, my team has treated approximately 350 patients in Kiryas Joel and another 150 patients in other areas of New York with the above regimen.

Of this group and the information provided to me by affiliated medical teams, we have had ZERO deaths, ZERO hospitalizations, and ZERO intubations. In addition, I have not heard of any negative side effects other than approximately 10% of patients with temporary nausea and diarrhea.

In sum, my urgent recommendation is to initiate treatment in the outpatient setting as soon as possible in accordance with the above. Based on my direct experience, it prevents acute respiratory distress syndrome (ARDS), prevents the need for hospitalization and saves lives.

With much respect, Dr. Zev Zelenko

Video: Coronavirus Treatment: New York Doctor Vladimir Zelenko Finds 100% Success Rate in 350 Patients Using Hydroxychloroquine with Zinc

3.1.2.. October 15, 2019, A triple drug combination targeting components of the nutrient-sensing network maximizes longevity.

The use of rapamycin, lithium, and trametinib extend lifespan of drosophila by their double and triple combinations. Double combinations of lithium and rapamycin, lithium and trametinib, or rapamycin and trametinib produced a reproducibly greater lifespan extension than controls, on average 30%, compared to each compound alone, which extended lifespan by an average of 11%. Importantly, the triple combination promoted lifespan by 48%.

3.1.3.. March 20, 2020, Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and reported to be efficient in Chinese COV-19 patients. We evaluate the role of hydroxychloroquine on respiratory viral loads.

Patients and methods

French Confirmed COVID-19 patients were included in a single arm protocol from early March to March 16th, to receive 600mg of hydroxychloroquine daily and their viral load in nasopharyngeal swabs was tested daily in a hospital setting. Depending on their clinical presentation, azithromycin was added to the treatment. Untreated patients from another center and cases refusing the protocol were included as negative controls. Presence and absence of virus at Day6-post inclusion was considered the end point.

Results

Six patients were asymptomatic, 22 had upper respiratory tract infection symptoms and eight had lower respiratory tract infection symptoms.

Twenty cases were treated in this study and showed a significant reduction of the viral carriage at D6-post inclusion compared to controls, and much lower average carrying duration than reported of untreated patients in the literature. Azithromycin added to hydroxychloroquine was significantly more efficient for virus elimination.

Conclusion

Despite its small sample size our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.

3.1.4.. Nov 22, 2013, Plant Nutrient 'Cocktail' Kills Breast Cancer Cells

The researchers at Louisiana State University tested six known protective chemical nutrients from turmeric, soybeans, broccoli, grapes and tea. Individually, they were ineffective against cancer. But combined, they suppressed breast cancer cell growth in the lab by more than 80 percent, and eventually triggered the process leading to cell death.”

3.1.5.. October 1999, Phytomedicine Research in Germany

In Germany since 1980, more than 300 clinical studies have been carried out with standardized phytopharmaceuticals and gotten promising results.

“Several comparative clinical trials showed that these phytopharmaceuticals had full therapeutic equivalence with chemotherapeutics and had the simultaneus advantage of being devoid of any adverse effects. The mechanism of action of herbal drugs and their extract preparations, which differ in many respects from that of synthetic drugs or mono substances, can be characterized as a polyvalent action and interpreted as additive or, in some cases, potentiating.”

“In many cases, the overall pharmacologic effects and therapeutic efficacies derived not from a single compound but from several compounds generating additive or synergistic pharmacologic effects.”

“Many phytopreparations exhibit no immediate pharmacologic or therapeutic effects and achieve their optimal efficacy only after long-term treatment” maybe caused by following reasons:

“Lack of potentiating synergistic effects by adding more bioactive constituents from other drugs, just as the principle of compound prescription of TCM.”

“Insufficient in drugs’ dose. Many natural drugs are no poisons and dose-dependent, which allowing to be used in a higher dose.”

“The therapeutic mechanism of the natural drugs is regulatory rather than allopathic, so that the effect only appeared after the overall physical condition being regulated back to normal. This point is the main advantage of natural drugs.”

The studies of Germans proved correctness of TCM in compound formula by using dozens of natural medicinals in one dose since thousands years ago.

Above studies confirmed the direction of the development of medication for fighting against COVID-19, by combining use of current available medications, rather than developing new one in huge cost, wasting time and negatively viewing people dying without hope sign.

At current situation, for ordinary people the easy available is daily diets.

3.1.6.. Vinegar, Vc, B3, and Chinese medicinals is the best curative for COVID-19 pneumonia

Jan. 26, 2020, I wrote article Vinegar, Vitamin C, B3, and Chinese medicinals is the best curative for 2019 new coronavirus and other acute and chronic diseases, in which I discussed the philosophy and the curative mechanism of TCM, and the combo use of Vinegar, vitamins and Chinese medicinals.

The edible vinegar, vitamins and Chinese medicinals all have their own therapeutic function when using individually and thus when combined use, they will produce more powerful therapeutic effect in far beyond expected. My suggestion is as below.

Daily 4 - 5 times 10 - 20 ml 5% vinegar adds 20 ml honey dilutes by 500 ml water orally drink (or outside smears water diluted vinegar to be absorbed through the skin, which will take effect more quickly), then gargle throat with water, 3 grams vitamin C in 6 times daily.

In above article, I discussed their pharmaceutical effects with LD50s.

At the time of the start of onset of the COCID-19 virus’ infection, the virus has not unduly damaged our body, if we take some vinegar or honey to enhance our body in physical and immunity, we may recover soon, at least do not be developed as acute with 50% possibility to be finished and may make medical staff infected.

At the beginning, vinegar has caused swelling in my throat. As I continue to drink vinegar, my body seems gradually adapt to it and the swelling has gradually decreased largely in drinking same amount of vinegar.

Googled vinegar in killing coronavirus got subjective assumptions without test data supporting, but Google vinegar boosts immunity and health benefits, got a lot. There is report that vinegar can destruct cell structure to kill bacteria and viruses.

In Canada, vinegar is used to disinfect production equipment of meats foods - Chicken, pork, beef, fish, etc., they are all extremely susceptible to germs and viruses, which can indirectly prove the antiviral effect of vinegar.

Though the property of vinegar killing COVID-19 is not clear yet, but its property in boosting immunity and enhancing physical condition will play a role as that of Chinese medicine in doing. I firmly believed that vinegar will be powerful bullet to finish 2019 novel coronavirus.

Vinegar and honey both have antiviral functions, but that may not be powerful enough. However, once combined with our autoimmunity, their effect may be better than any synthetic drug, and also there is no fatal harm from the side effects of synthetic drugs.

According to my personal experience, vinegar can immediately stop a runny nose, eliminate sticky sputum that can't be coughed out in the throat, and thereby reducing snoring and apnea. The nasal cavity and throat are the main channels for the virus to invade, and vinegar can naturally kill them in there.

Autopsy showed that a large amount of mucus blocked the bronchial airway inside the lungs, and then asphyxia caused the death of patients with new coronary pneumonia. Vinegar can eliminate snot and sticky sputum; it certainly can reduce the mucus from the bronchial airway inside the lungs.

Feb. 29, 2020, the Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) said that the air is not the transmitting vector, the most of infections on COVID-19 is from families and infected people develop signs and symptoms of fever and mild respiratory symptoms, on an average of 5 - 6 days.

The evidence that the air is not the transmitting vector, the families' contact is main cause and the incubation period of 5 to 6 days provide us with the opportunity to prevent the onset of pneumonia by taking certain amount of vinegar daily and treating family members of each other as infected to disinfect hands and utensils with vinegar.

The increasingly confusion and chaotic in fighting against the COCID-19 virus globally is caused by the misleading of the medical guidance of the philosophy Reductionism of western medicine,

Reductionism views human body as a non-living mechanical assembly with an inhuman perspective, and by seeking pathogens for killing as a cure, that is, it has been treating humans as non-living life. Under such a philosophy, humans would never get rid of the torture of pathogens.

The philosophy of traditional Chinese medicine is Daoism that is exactly in opposite of the Reductionism; it cherishes human body as a living life, and by trying to restore the balance of yin and yang of human body as the treatment. It is the correct philosophy in guiding Chinese medicine to successfully save lives.

Besides the needles of acupuncture and natural Chinese medicinals, still there are many therapies available.

The solution for defeating 2019 new coronavirus lies not in technological breakthroughs but in getting rid of ideological constraints of scientific or unscientific. Such ideologies are hallucinogens in misleading people going on wrong way in disease treatment by overemphasizing on killing pathogens by neglecting the enhancement of body's natural immunity, and overemphasizing on synthetic medications by abandoning natural and traditional medicinals.

In Japan, by asthma drug steroid inhalant Ciclesonide cured oxygen supported patients in COVID-19 pneumonia according to the report Asthma drug seems effective for COVID-19 pneumonia in Mar. 3, 2020.

In a remote village of Iran, according to the advice of elderly, by bee stings cured six sufferers in COVID-19 pneumonia, which is from a post followed article How to respond to COVID-19 on the Blog of Bill Gates.

3.2.. The availability of existing medications for fighting against COVID-19

3.2.1.. Natural Chinese medicinals

In China, from the clinical experiences, some formulas in the combo of Chinese medicinals have been recommended by the senior medical expert team.

3.2.2.. Redmdesivir

3.2.2.1.. A cured case from Manhattan New York City

James Cai @JamesCaiNJNYC

https://twitter.com/JamesCaiNJNYC/status/1241451277625819136

I am the first case of COVID19 in NJ and thanks to everyone who made it possible, I was fortunate enough to be treated with Redmdesivir. This med was a KEY component to my treatment and I am getting discharged today after finally testing neg x 2.

About the patient from the Mandarin articles

This is translated reedited from Mandarin article

James Cai, 32, a medical assistant lives and works in Manhattan. He has been hospitalized since March 3. 2020. He does not smoke and has no underlying health conditions. He was convinced that he had contracted the virus while attending a medical conference in Times Square.

"It happened too quickly, the virus was everything: diarrhea, tears, shortness of breath, chest pain, high fever. ... The condition was once critical and worsening every day."

Initially, the hospital treated him with "chloroquine" and the anti-AIDS drug "Kaletra" to slow down the onset of the virus in the body, and then took " Redmdesivir " since March 11, for 8 days.

After the first dose, the fever decreased and all laboratory tests were all symptoms improved after one day.

James Cai hopes that "Redmdesivir" can be used more widely in patients. "The time to treat new coronary pneumonia is very important. There is not much time left now. We must use the available resources to save lives.

Note: The use of Redmdesivir was achieved after James Cai openly appealed on public media in despair voice, the most of the doctors will treat patients by the safe way of avoiding being sued, rather than the safe of the life of patients.

3.3.2.2.. Remdesivir and chloroquine can inhibit 2019-nCoV) in vitro

February 4, 2020, Cell Research volume 30 published article Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.

“Our findings reveal that remdesivir and chloroquine are highly effective in the control of 2019-nCoV infection in vitro. Since these compounds have been used in human patients with a safety track record and shown to be effective against various ailments, we suggest that they should be assessed in human patients suffering from the novel coronavirus disease.

3.2.2.3.. 61 patients, 47% discharged and oxygen-supported 68% improved

April 10, 2020, Compassionate Use of Remdesivir for Patients with Severe Covid-19

Dr. Brainard at Gilead Sciences, 333 Lakeside Dr., Foster City, CA 94404, diana.brainard@gilead.com

ABSTRACT

BACKGROUND

Remdesivir, a nucleotide analogue prodrug that inhibits viral RNA polymerases, has shown in vitro activity against SARS-CoV-2.

METHODS

We provided remdesivir on a compassionate-use basis to patients hospitalized with Covid-19, the illness caused by infection with SARS-CoV-2. Patients were those with confirmed SARS-CoV-2 infection who had an oxygen saturation of 94% or less while they were breathing ambient air or who were receiving oxygen support. Patients received a 10-day course of remdesivir, consisting of 200 mg administered intravenously on day 1, followed by 100 mg daily for the remaining 9 days of treatment. This report is based on data from patients who received remdesivir during the period from January 25, 2020, through March 7, 2020, and have clinical data for at least 1 subsequent day.

RESULTS

61 patients who received at least one dose of remdesivir, data from 8 could not be analyzed (including 7 patients with no post-treatment data and 1 with a dosing error). Of the 53 patients whose data were analyzed, 22 were in the United States, 22 in Europe or Canada, and 9 in Japan. At baseline, 30 patients (57%) were receiving mechanical ventilation and 4 (8%) were receiving extracorporeal membrane oxygenation. During a median follow-up of 18 days, 36 patients (68%) had an improvement in oxygen-support class, including 17 of 30 patients (57%) receiving mechanical ventilation who were extubated. A total of 25 patients (47%) were discharged, and 7 patients (13%) died; mortality was 18% (6 of 34) among patients receiving invasive ventilation and 5% (1 of 19) among those not receiving invasive ventilation.

CONCLUSIONS

In this cohort of patients hospitalized for severe Covid-19 who were treated with compassionate-use remdesivir, clinical improvement was observed in 36 of 53 patients (68%). Measurement of efficacy will require ongoing randomized, placebocontrolled trials of remdesivir therapy. (Funded by Gilead Sciences.)

3.2.3.. Hydroxychloroquine

March 20, 2020, Will an old malaria drug help fight the coronavirus?

Nivaquine tablets containing chloroquine, a commonly used malaria drug that has shown signs of effectiveness against coronavirus, according to a study conducted in several Chinese hospitals.

Hydroxychloroquine has been used for around 70 years to treat malaria, rheumatic conditions and other ailments. Now its potential use in the fight against coronavirus has become a source of hope for many, following encouraging results from a clinical trial in France. But experts caution that there is still uncertainty about its effectiveness.

A very old drug is coming back to the fore. The successful testing of hydroxychloroquine for use against the coronavirus in France’s second city Marseille on March 16 created high expectations amid this surging epidemic – especially in light of Donald Trump’s announcement on Thursday that the US Food and Drug Administration has approved its use for this purpose.

3.2.3.1.. Hydroxychloroquine made cough, fever and pneumonia went away faster

April 1, 2020, a report that Malaria Drug Helps Virus Patients Improve, in Small Study said that “A group of moderately ill people were given hydroxychloroquine, which appeared to ease their symptoms quickly, but more research is needed.”

“The malaria drug hydroxychloroquine helped to speed the recovery of a small number of patients who were mildly ill from the coronavirus, doctors in China reported this week.”

“Cough, fever and pneumonia went away faster, and the disease seemed less likely to turn severe in people who received hydroxychloroquine than in a comparison group not given the drug. The authors of the report said that the medication was promising, but that more research was needed to clarify how it might work in treating coronavirus disease and to determine the best way to use it.”

The new study, of 62 patients with an average age of about 45, did have a control group. It was conducted at the Renmin Hospital of Wuhan University, in Wuhan, China. The patients were carefully chosen to exclude people with medical problems that could be made worse by hydroxychloroquine, like abnormal heart rhythms, certain eye diseases, and liver or kidney problems.

Half the subjects — the controls — received just the usual care given to coronavirus patients, and half had usual care plus hydroxychloroquine. The usual care included oxygen, antiviral drugs, antibiotics and other treatments.

Their disease was considered mild, even though all had pneumonia that showed up on CT scans. After giving informed consent, they were assigned at random to either the hydroxychloroquine or the control group. They were treated for five days, and their fevers and coughing were monitored. They also had chest CT scans the day before the study treatment began, and the day after it ended.

Coughing and fever eased a day or so earlier in the patients who received hydroxychloroquine, and pneumonia improved in 25 of 31, as opposed to 17 of 31 in the controls.

The illness turned severe in four patients — all in the control group.

Two patients had minor side effects from hydroxychloroquine: One had a rash and another had a headache.

Dr. Schaffner cautioned that the results applied only to patients with relatively mild illness, like the ones in the study, and could not be generalized to advanced cases.

“If you want to treat people who are already seriously ill, we don’t know how well this will work,” he said.

If the drug is helping, it is not clear how. There are two possible ways. In laboratory studies, it can stop the virus from invading cells. But hydroxychloroquine can also dial back an overactive immune system, which is why it can treat autoimmune diseases. And a powerful immune reaction to the coronavirus is suspected of playing a role in some of the severest cases of the disease.

”We don’t know which of the pharmacologic aspects of hydroxychloroquine are most active, the antiviral part, or the immunomodulatory part,” Dr. Schaffner said. “We don’t know, but it does reinforce the notion, as the authors say briefly, it reinforces the thinking about the nature of many of these pneumonias we are seeing, which seem to have an immune basis, as opposed to being secondary bacterial pneumonia, which we see so often in influenza.”

3.2.3.2.. Hydroxychloroquine effectively cured patients from overseas in China

On April 5, 2020, a Mandarin article reports that the treatment of overseas imported cases achieved good results in Shanghai: the Shanghai plan was again verified, accurate and effective.

A total of 27 confirmed cases in Shanghai were cured and discharged today, in which 26 cases were imported cases abroad, and 1 case was infected by imported case abroad. As of today, 383 people have been discharged.

Abroad imported cases have their own characteristics. Due to the lack of direct flights, some patients have been transited in many countries and have been in the cabin for nearly 30 hours or longer without eat, drink or use the toilet, which has a great impact on the body's immunity.

Some patients are starved in hypoalbuminemia, some even have ketosis, and the body's normal immunity is destroyed.

All patients are treated with hydroxychloroquine to reduce the occurrence of severe cases. Hydroxychloroquine is called as a particularly effective drug,

For patients with early coagulopathy, treated by combined use anticoagulation, heparin and vitamin C, etc., plus oxygen therapy, thymus peptide immunotherapy, etc., as far as possible avoids mild patients from becoming acute state.

3.2.3.3.. Home self-cured patient by Hydroxychloroquine

On April 3, 2020, a Mandarin article Like a hammer hits the chest, Chinese man successfully self-cured by Hydroxychloroquine.

Randy Chen, 50, began to experience symptoms such as body aches and coughs on March 15. He immediately moved to the basement to isolate himself. His temperature exceeded 101 degrees Fahrenheit in the afternoon of the next day, and he was confirmed on March 19. From March 21 to 23, his condition deteriorated rapidly, and the frequency of coughing reached once every five minutes, so that he could only fall asleep for two hours a day. His body shivered unconsciously, and his chest seemed to be hit by a hammer. Because of his severe discomfort, he once can't reply to his wife's text messages。

In order to prevent the spread of the virus, his wife placed the meal on the stairs and sent him a text message. Knowing that oxychloroquinine can treat new coronary pneumonia, but the United States was out of stock; on March 24, he received oxychloroquinine that his relative sent in Taiwan and he took one capsule twice a day in every eight hours.

After taking medicine, he could sleep peacefully, and his chest pain was reduced. On March 25, he lost his sense of smell and taste returned again after lost two weeks. Body temperature has returned to normal for many days.

3.2.4.. Abidol

Mar. 18, 2020, a Mandarin article Home Self-Healing Doctor Zhang Jinnong: I Have Antibodies

In Jan. 2020, Zhang Jinnong, director of the emergency department of Wuhan Union Medical College Hospital, contracted with new crown pneumonia, and quickly took measures after finding the infection. Because of the mild symptoms and his own expertise, he chose to isolate himself at home by strict protection, he did not infect others.

The first one is isolated by living in a suite of department; the second one wears a mask.

There are two benefits of wearing a mask, the first one is that does not pass to others, and the second one is that prevents other pathogenic microorganisms from entering again.

Home isolation is very effective. When the time other people delivering foods to his door, he don't open the door.

During his home isolation, he was still participating in the hospital's case discussions, guiding consultations, thinking about how to prevent and cure scientifically, and turning his illness into clinical experience. In the sixth edition of the diagnosis and treatment plan issued by the senior medical expert team, the drug Abidol is included in the antiviral treatment, which is the one that Zhang Jinnong tried out when he was in isolation.

He said that after taking Abidol, his throat felts comfortable.

After recovery, he work with wore little protection and he said that he did not waste protective clothing because that he had antibodies. More than a dozen people in the emergency department were infected, but, no one was heavy or oxygenated. Dr. Zhang encourage other doctors with that, he was almost 60 years old, he did not die, you all won’t die, please don’t be afraid, once you infected, I will cure you.

3.2.5.. Asthma drug steroid inhalant Ciclesonide

In Japan, by asthma drug steroid inhalant Ciclesonide cured oxygen supported patients in COVID-19 pneumonia according to the report Asthma drug seems effective for COVID-19 pneumonia in Mar. 3, 2020.

3.2.6.. The sting of Honey Bee

I copy the post as below.

Ehsan Ashkani 3 hours

Hello, I live in a remote village in Iran Corona virus is spreading all over the cities Small and big cities are involved Our government figures are all lies, we have no facilities, especially in remote villages and villages And they don't go to the hospital because they make us worse, and then they don't even say it's because of a coronary virus. In our village, people treat my grandmother's advice, which collects traditional medicine from the mountains and the desert. Six sick people from our village treated with bee stings and now they are well Well, I wanted to send this message and maybe find someone or somewhere I don't know. Maybe there are many places on this planet that are deprived of basic facilities because of people with coronavirus and lack of facilities and equipment. Use Bee Bite Now Only Be Careful Those who have allergies and allergies to bee stings are doing so dangerous, goodbye to everyone.

Frank Li to Ehsan Ashkani 35 minutes

I think that you should organize those who are cured in your village, take bees, to go to big cities, such as, Tehran to treat people with new coronavirus infected. It is reasonable to charge a certain amount of money. It is not mandatory, but voluntarily, the Rich people may give more, since that you provided is reliable cure. Now, the environment in Tehran is scary. For villagers who are willing to go to Tehran to treat others, by collecting some money as psychological comfort, otherwise there is no one would like to withstand such a psychological panic.

3.2.7.. Jun, 2015, Vitamin D for influenza

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463890/

A colleague of mine and I have introduced vitamin D at doses that have achieved greater than 100 nmol/L in most of our patients for the past number of years, and we now see very few patients in our clinics with the flu or influenzalike illness. In those patients who do have influenza, we have treated them with the vitamin D hammer, as coined by my colleague. This is a 1-time 50 000 IU dose of vitamin D3 or 10 000 IU 3 times daily for 2 to 3 days. The results are dramatic, with complete resolution of symptoms in 48 to 72 hours. One-time doses of vitamin D at this level have been used safely and have never been shown to be toxic.8 We urgently need a study of this intervention. The cost of vitamin D is about a penny for 1000 IU, so this treatment costs less than a dollar.

3.2.8.. Life Assitant Vitamin C

Role in immunity of Vitamin C from Linus Pauling Institute, Oregon State University

https://lpi.oregonstate.edu/mic/vitamins/vitamin-C#role-in-immunity

Vitamin C affects several components of the human immune system in vitro; for example, vitamin C has been shown to stimulate both the production and function of leukocytes (white blood cells), especially neutrophils, lymphocytes, and phagocytes. Specific measures of functions stimulated by vitamin C include cellular motility, chemotaxis, and phagocytosis.

Neutrophils, mononuclear phagocytes, and lymphocytes accumulate vitamin C to high concentrations, which can protect these cell types from oxidative damage. In response to invading microorganisms, phagocytic leukocytes release non-specific toxins, such as superoxide radicals, hypochlorous acid ("bleach"), and peroxynitrite; these reactive oxygen species kill pathogens and, in the process, can damage the leukocytes themselves. Vitamin C, through its antioxidant functions, has been shown to protect leukocytes from self-inflicted oxidative damage.

Phagocytic leukocytes also produce and release cytokines, including interferons, which have antiviral activity. Vitamin C has been shown to increase interferon production in vitro. Additional studies have reported that vitamin C enhances the chemotactic and microbial killing capacities of neutrophils and stimulates the proliferation and differentiation of B- and T-lymphocytes.

High Dose Vitamin C and Influenza: A Case Report

From the Journal of Molecular Biology, Volume 34, Number 2, 2019.

M.G., a 25-year-old forensic psychologist from Ponce, Puerto Rico, was in his baseline state of excellent health when he began to notice classical flu-like symptoms, including fever, chills, muscle aches and pains, headaches, and nausea. He fought these symptoms as best as he could for a week. However, by the time this period had passed, he only had the energy to stay in bed with constant headaches and body pain. As it was, he went from approximately 170 pounds down to 155 pounds.

A rapid flu swab test was done which turned out positive. We treated him with Intravenous Vitamin C (IVC) therapy which consisted of 1,000 cc of lactated Ringer’s solution containing 50 grams of sodium ascorbate, a pH-neutral form of vitamin C. This was infused over about one and a half hour. This same regimen was repeated for a total of 3 infusions over 3 days. All of the infusions were clinically uneventful and without discernible side effects.

The morning following the first IV, the patient noted that his body strength had improved dramatically. He also noticed that his headaches were gone. The morning after the second IV his appetite was improving and he was eating more as well.

All of the IVC infusions were given at the patient’s home. On day four he felt normal, but Vitamin C was continued to be given orally (2 g tid). The patient was also instructed to start taking a high potency multivitamin and mineral (1qd) in addition to CoQ10 (100mg qd) on a regular basis orally. In addition to Echinacea (500 mg bid for ten days).

3.2.9.. Acupoints injection of Phenol

In China, Doctor Li Yuehua cured many COVID-19 infected by trace amount of Phenol and he dared not wear a mask when treating COVID-19 infected patients.

Dr. Li graduated from Third Military Medical University in 1987, and then he worked as clinic doctor.

In 2004, after many times trial, he found that using a small amount of phenol (5 to 10 / 10,000) as an acupoint injection, with 0.5 ml per acupoint, can treat a variety of diseases, especially for various viral diseases. He guessed this is a broad-spectrum antivirus treatment.

He explained that viruses are mainly divided into the form of DNA and RNA. No matter which virus, they have at least one basic group containing a pyrimidine ring.

The chemical structure of phenol is a benzene ring plus a hydroxyl. The benzene ring is very similar to the pyrimidine structure, therefore, phenol can be used to block virus replication, and a trace amount of phenol can be injected to treat viral diseases.

Phenol is toxic and used as disinfectant in the disinfection of medical equipment with has a great side effect on the body. The internationally prescribed concentration of 5% to 10% phenol solution can be used for clinical purposes, as long as the dose of injection does not exceed 5 ml.

The concentration of phenol injection used by Li Yuehua to treat patients with new crowns pneumonia is 100 times lower than international regulations, so the safety is very high.

http://www.bjnews.com.cn/inside/2020/03/05/699418.html

3.2.10.. Ivermectin shows activity against COVID-19 in cell cultures

A study has demonstrated that the anti-parasitic drug ivermectin may be effective against SARS-CoV-2, the virus which causes COVID-19.

Researchers have discovered ivermectin, an anti-parasitic drug found world-wide, can kill SARS-CoV-2, the virus causing the COVID-19 pandemic, within 48 hours.

A collaborative study by Monash University’s Biomedicine Discovery Institute (BDI) and the Peter Doherty Institute of Infection and Immunity (Doherty Institute), both Australia, demonstrated that ivermectin can stop SARS-CoV-2 growth in cell cultures by eradicating all genetic information within two days. Their findings were published in Antiviral Research.

“We found that even a single dose could essentially remove all viral RNA by 48 hours and that even at 24 hours there was a really significant reduction in it,” said BDI’s Dr Kylie Wagstaff, who led the study.

Ivermectin is a US Food and Drug Administration (FDA)-approved anti-parasitic drug that has previously shown activity in vitro against a broad range of viruses, including human immunodeficiency virus (HIV), Dengue fever, influenza and Zika virus. Dr Wagstaff stated: “Ivermectin is very widely used and seen as a safe drug. We need to figure out now whether the dosage you can use it at in humans will be effective – that’s the next step.”

According to Dr Wagstaff, the mechanism of action by which ivermectin targets SARS-CoV-2 is unknown; however, it is thought to be similar to how it works on other viruses – preventing the virus dampening down the host cells’ ability to clear it.

Dr Wagstaff worked with Professor David Jans, also an author on the paper, to conduct the research. Professor Jans and his team have been researching ivermectin’s antiviral properties for more than 10 years with different viruses. The pair said they began their work on SARS-CoV-2 as soon as the pandemic was reported to have started.

Dr Wagstaff concluded by cautioning that the use of ivermectin to combat the COVID-19 pandemic will depend on further pre-clinical and clinical testing which will require funding.

3.2.11.. The effect of Vinegar in antimicrobial activity and autoimmune activity

3.2.11.1.. Vinegar mixes honey is ancient medicine for persistent coughs

May 30, 2006, Vinegar: Medicinal Uses and Antiglycemic Effect

The use of vinegar to fight infections and other acute conditions dates back to Hippocrates (460-377 BC; the father of modern medicine), who recommended a vinegar preparation for cleaning ulcerations and for the treatment of sores.

Oxymel, a popular ancient medicine composed of honey and vinegar, was prescribed for persistent coughs by Hippocrates and his contemporaries, and by physicians up to modern day. The formulation of oxymel was detailed in the British Pharmacopoeia (1898) and the German Pharmacopoeia (1872), and, according to the French Codex (1898), the medicine was prepared by mixing virgin honey, 4 parts, with white wine vinegar, 1 part, concentrating and clarifying with paper pulp.

3.2.11.2.. Apple cider vinegar (ACV) impaired cell integrity, organelles and protein expression

Jan. 29, 2018, Sci Rep. 2018; 8: 1732. Antimicrobial activity of apple cider vinegar against Escherichia coli, Staphylococcus aureus and Candida albicans; downregulating cytokine and microbial protein expression

For C. albicans, a 1/2 ACV had the strongest effect, S. aureus, a 1/25 dilution ACV was required, whereas for E-coli cultures, a 1/50 ACV dilution was required (p < 0.05). Monocyte co-culture with microbes alongside ACV resulted in dose dependent downregulation of inflammatory cytokines (TNFα, IL-6).

Results are expressed as percentage decreases in cytokine secretion comparing ACV treated with non-ACV treated monocytes cultured with E-coli (TNFα, 99.2%; IL-6, 98%), S. aureus (TNFα, 90%; IL-6, 83%) and C. albicans (TNFα, 83.3%; IL-6, 90.1%) respectively.

Proteomic analyses of microbes demonstrated that ACV impaired cell integrity, organelles and protein expression. ACV treatment resulted in an absence in expression of DNA starvation protein, citrate synthase, isocitrate and malate dehydrogenases in E-coli; chaperone protein DNak and ftsz in S. aureus and pyruvate kinase, 6-phosphogluconate dehydrogenase, fructose bisphosphate were among the enzymes absent in C.albican cultures. The results demonstrate ACV has multiple antimicrobial potential with clinical therapeutic implications.

Severe infections, autoimmunity or transplantation can inevitably lead to ineffective immunity in patients. An analysis of macrophages from Crohn’s disease patients revealed that they had defective responses to E-coli due to Crohn’s related systemic immunosuppression.

A recent report showed that co-administration of ACV with L-casei boosted systemic and mucosal immune responses, antioxidant enzyme and growth genes in fish. Equally, perhaps additive dietary supplementation with ACV could be of benefit in acute infections, autoimmune induced immune dysregulation or antibiotic redundancy in humans.

ACV has multiple antimicrobial properties on different microbial species, affecting microbe growth, suppressing mononuclear cytokine and phagocytic responses. The tandem mass spectroscopy results are in cohesion with these observations.

The microbes underwent significant impairment following ACV addition which damaged cell integrity, structural and metabolic proteins as well as nuclear material.

Indeed the enzymes citrate synthase, isocitrate dehydrogenase, malate dehydrogenase, aminomethyltransferase and formate acetyltransferasesuccinyl-CoA ligase are crucial for E-coli growth, gene regulation and central, intracellular carbon metabolism.

An absence of these enzymes would affect glycolytic, tricarboxylic acid cycle, pentose phosphate, glycoxlate shunt and oxidative phosphorylation pathways in E. coli. Furthermore, the absence of DNA binding protein from starved cells, is significant as it protects E-coli and functions to control gene regulation during cell starvation. With respect to other proteins, we observed the presence of ribosomal proteins (L1, L6 and 30 s ribosomal proteins (S1, S4, S6, S7, S8, S11) in ACV treated E. coli compared to control E. coli.

These are mostly RNA binding proteins hence their presence could have been due to partial disintegration of 50 s and 30 s ribosomal breakdown whereas these subunits might remain intact in untreated E. coli cultures. The absence of ribosome associated inhibitor A could interrupt E. coli growth cycles as it serves to minimise translational errors. Collectively these results support the cytotoxic effects of ACV we observed on E-coli. ACV treated S. aureus cultures did not express the chaperone protein Dnak and the cell division protein ftsz. This is significant as previous studies have shown that a non-functional DnaK system can cause a reduced tolerance to heat, oxidative, antibiotic stresses and lowered carotenoid production.

There was also an absence of gateway enzymes involved in multiple pathways such as ornithine aminotransferase. 6 phosphogluconate dehydrogenase decarboxylating was expressed which is not surprising as it plays a critical role in protecting cells from oxidative stress. The effect of ACV on C.albican protein moieties was less dramatic, nevertheless we did detect the absence of key enzymes which are fundamental in maintaining cell integrity and biosynthetic pathways.

There could be a strong possibility that ACV acts like other anti-pathogenic compounds in diverting monocyte responses through toll receptor signalling pathways. There is evidence that E-coli in particular can induce a typical M1 monocyte profile through mechanisms involving NF-kB activation. This results in upregulation of inflammatory cytokines TNF-α and PI3 kinase stimulation.

The in vitro M1 monocyte phenotype is also prominent in severe sepsis. This was shown in a study using baboons where a substantial mortality rate correlated with high serum levels of TNFα and IL-6 following induced sepsis infection. Unchecked high levels of circulating M1 cytokines can rapidly lead to cardiac arrest and death hence any factor capable of lowering pro-inflammatory cytokine concentrations is essential in therapy. It has been reported that ACV consists of acetic acid, flavonoids such as gallic acid, tyrosol catechin, epicatechin, benzoic acid, vaninilin, caftaric acid, coutaric acid, caffeic acid, acid and ferrulic acid These constituents have been reported to affect immune defence and oxidative responses.

Furthermore, the mechanism of ACV activity could be attributed in part to the apple polyphenol content. Yang et al. (2010) reported on the cellular protective effects of apple polyphenols on induced liver damage whereby histopathological tissue destruction was limited and liver activity maintained in mice that received the polyphenols. The mechanisms involved were free radical scavenger action, lipid peroxidation modulation and the antioxidant upregulation capacity of ACV.

Interestingly, a study by Denis et al. demonstrated the anti-inflammatory potential of apple phenols on gastrointestinal cell inflammation which involved downregulation of TNF and IL-6 cytokines. Another means of action could involve the acetic acid component of ACV which is able to reduce the cell hydrogen potential hence could potentially facilitate diffusion across the plasma membrane of microbes.

Furthermore, there is evidence that organic acids can alter immune responses by binding to GPR3, a G protein coupled receptor which is mostly expressed on inflammatory leukocytes. Also, an investigation reported on upregulated blood and plasma antioxidant enzyme release after apple consumption which would encourage immune protection16.

The positive benefits of dietary ACV supplementation have been highlighted in vivo. ACV decreased the serum lipid profile in mice fed a high cholesterol diet over 28 days. Intragastric ACV addition induced a protective effect against erythrocyte, kidney and liver oxidative injury as well as lowering cholesterol levels. ACV also decreased blood triglyceride and very low density lipoprotein levels in rats which had induced cholesterol induced hepatic steatosis. In an infection induced model of denture stomatitis, ACV addition resulted in anti-fungal activity against Candida Spp which was comparable to nystatin in terms of reducing microbial adherence and destruction.

We conclude that ACV can have multiple antimicrobial effects directly on E-coli, S. aureus and C. albicans. ACV addition can also decrease induced inflammatory cytokine release during mononuclear leukocyte infection and increases monocyte phagocytic capacity. Mechanisms include alteration of the microbial protein physiology destroying structural pathogenic proteins and metabolic enzymes. Collectively our results highlight the potent antimicrobial and therefore beneficial actions of ACV. This preliminary study encourages further work on dietary ACV supplementation investigating its antimicrobial role and the constituents which could be responsible for this activity.

3.11.3.. Treatment of flu and meningitis with vinegar steaming in army barracks

In term of vinegar in Dictionary of Traditional Chinese Medicine, there is section of prevention of influenza and epidemic cerebrospinal meningitis by vinegar steaming in army barracks.

http://www.zysj.com.cn/zhongyaocai/yaocai_c/cu.html

Studies show that vinegar fumigation has a good killing effect on influenza viruses with bactericidal effect on five types of bacteria such as Streptococcus A, catarrhalis, Pneumococcus, Staphylococcus albicans and Bacillus influenzae.

Close the doors and windows, takes appropriate amount of vinegar (2 to 10 ml per cubic meter of space), dilute with 1 to 2 times the water, heat to fumigate, 1 hour each time, once a day or every other day for 3 to 6 consecutive days.

In the season of spring and winter, there 13 infantry companies were infected influenza in the army, and 12 companies had the epidemic controlled on the second day after vinegar fumigation; while the another company had not applied it, the result was 60% of the people infected after 2 days. After vinegar fumigation the epidemic was quickly controlled on the third day.

During the epidemic of cerebrospinal meningitis, there 84 carriers were treated by vinegar-fumigating twice a day for 10 consecutive days, and all carriers were returned to negative.

3.11.4.. Vinegar raised total erythrocyte counts and total leukocyte counts

April 11, 2001, J Egypt Public Health Assoc. The effect of cider vinegar on some nutritional and physiological parameters in mice.

Groups of female ICR (CD-1) mice were treated with daily oral doses of 0.17, 0.51 and 1.02 ml of the vinegar/kg body weight for 4 weeks.

Cider vinegar induced a significant reduction in weight gain in animals treated with 0.51 ml/kg while others showed no significant differences in weight gain.

The mean dry matter intake increased in animals treated with the smallest dose and significantly decreased in others.

Hemoglobin (Hb), total erythrocyte counts (TEC) and total leukocyte counts (TLC) were raised in all treated groups.

The activity of liver aspartate amino transferase (AST) decreased in the group treated with the smallest dose while no significant variations were recorded in the other groups.

No significant differences were recorded neither in the activity of hepatic alanin amino transferase (ALT) nor in hepatic acid phosphatase (ACP).

Liver alkaline phosphatase (ALP) noticeably elevated only in animals treated with 0.51 ml of vinegar/kg body weight per day.

Treated groups also showed statistically significant increases in both mean liver and spleen weight. Kidney weight did not show significant differences.

High doses of cider vinegar induced histopathological alterations in liver, stomach and duodenum. Vacuolated hepatocytes, erosion of gastric mucosa, dilatation in gastric glands and duodenum villus blunting are the common observed lesions noticed in organs of high dose-treated animals.

3.3.. About the use of Chloroquine and Hydroxychloroquine in curing COVID19

In section 3.2.3.. Hydroxychloroquine, I introduced about clinical use of hydroxychloroquine, in Shanghai hospital it is called as magic curative and used for all patients; and also there were cured cases in home self-treatment by hydroxychloroquine.

3.3.1.. China’s hospitals combine-use many medications in treating COVID19 at same time

There report that in China’s hospital, at the same time, there many medication combine-used in the treatment. Below was a report.

Mar 26, 2020, Did chloroquine really fail a COVID-19 study—or was the trial design to blame?

https://www.fiercepharma.com/pharma-asia/did-chloroquine-really-fail-a-covid-19-study-or-was-it-just-trial-design-s-fault

The report said that, “most patients in the study's control group were actually treated with other antiviral therapies at the same time, including AbbVie’s HIV combo med Kaletra and flu drug Arbidol. Most, but not all, patients in the hydroxychloroquine group were also treated with Arbidol. All patients got interferon-alpha.”

It is that massive combination of the medication reduced the side effects and promoted the curative effect of Chloroquine and Hydroxychloroquine.

More importantly, the doctors of China are carefully observing the condition of patients after gave medication and timely gave new medication to treat new symptoms, which is why that Chloroquine and Hydroxychloroquine caused heavy side effect and even killed people in some countries and thus stopped the use; but in China, the Hydroxychloroquine clinically proved and being called as magic cure to be used for all patients in Shanghai hospital.

3.3.2.. Hydroxychloroquine is effective in inhibiting SARS-CoV-2 in vitro

18 March 2020, Cell Discovery volume 6 published article Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro.

“Clinical investigation found that high concentration of cytokines were detected in the plasma of critically ill patients infected with SARS-CoV-2, suggesting that cytokine storm was associated with disease severity. Other than its direct antiviral activity, HCQ (Hydroxychloroquine) is a safe and successful anti-inflammatory agent that has been used extensively in autoimmune diseases and can significantly decrease the production of cytokines and, in particular, pro-inflammatory factors.”

“Therefore, in COVID-19 patients, HCQ may also contribute to attenuating the inflammatory response. In conclusion, our results show that HCQ can efficiently inhibit SARS-CoV-2 infection in vitro. In combination with its anti-inflammatory function, we predict that the drug has a good potential to combat the disease. This possibility awaits confirmation by clinical trials. We need to point out, although HCQ is less toxic than CQ, prolonged and overdose usage can still cause poisoning. And the relatively low SI of HCQ requires careful designing and conducting of clinical trials to achieve efficient and safe control of the SARS-CoV-2 infection.”

In faced with no effective treatment available, the use of effective drugs must be boldly trial, rather than simply sentence as death penalty or endless arguments.

In compared with the practice of the doctors of China, the practice of Sweden and France is too simple to explore feasible cure.

3.3.3.. The clinical trial of China shows that hydroxychloroquine in 400 mg/d is good

April 10, 2020. Renmin Hospital of Wuhan University; 94611960@qq.com published article Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial

Main methods: From February 4 to February 28, 2020, 62 patients suffering from COVID-19 were diagnosed and admitted to Renmin Hospital of Wuhan University. All participants were randomized in a parallel-group trial, 31 patients were assigned to receive an additional 5-day HCQ (400 mg/d) treatment, Time to clinical recovery (TTCR), clinical characteristics, and radiological results were assessed at baseline and 5 days after treatment to evaluate the effect of HCQ.

Key findings: For the 62 COVID-19 patients, 46.8% (29 of 62) were male and 53.2% (33 of 62) were female, the mean age was 44.7 (15.3) years. No difference in the age and sex distribution between the control group and the HCQ group. But for TTCR, the body temperature recovery time and the cough remission time were significantly shortened in the HCQ treatment group. Besides, a larger proportion of patients with improved pneumonia in the HCQ treatment group (80.6%, 25 of 31) compared with the control group (54.8%, 17 of 31). Notably, all 4 patients progressed to severe illness that occurred in the control group. However, there were 2 patients with mild adverse reactions in the HCQ treatment group.

Significance: Among patients with COVID-19, the use of HCQ could significantly shorten TTCR and promote the absorption of pneumonia.

3.3.4.. Swedish Hospitals Stopped Using Chloroquine after reports of severe side effects

April 6, 2020, there was a report that Some Swedish Hospitals Have Stopped Using Chloroquine to treat COVID19 after reports of severe side effects: “Several hospitals in Sweden have reportedly stopped administering chloroquine to coronavirus patients following reports the drug was causing adverse side effects.”

A 40-year-old Stockholm resident was diagnosed with COVID-19 on March 23 and was prescribed two tablets of chloroquine to take daily. But instead of making him feel better, the medication produced unpleasant side effects. As well as cramps and vision loss, Sydenhag experienced a headache that felt like that stepped into "a high voltage plant."

Magnus Gisslén, a professor and chief physician at Sahlgrenska University Hospital infection clinic, said that "There were reports of suspected more serious side effects than we first thought," he told the Gothenburg Post on April 1, 2020. "We cannot rule out serious side effects, especially from the heart, and it is a hard-dosed drug. In addition, we have no strong evidence that chloroquine has an effect on COVID-19."

This is despite the fact that the drugs have achieved mixed results in scientific studies. One study suggested it provides no additional benefit to patients who are already receiving care and being treated with antiviral drugs.

Another from researchers in France that has been widely cited by those in favor of using the chloroquine and hydroxychloroquine found the drugs dramatically lower viral load in COVID-19 patients. However, it has been criticized for its poor design, The Financial Times reports.

A paper published last week went even further, disputing its claims and finding no evidence of antiviral clearence or clinical benefit of using hydroxychloroquine and azithromycin to treat COVID-19.

3.3.5.. French Hospital Stops Hydroxychloroquine Treatment for COVID-19

April 8, 2020, French Hospital Stops Hydroxychloroquine Treatment for COVID-19 Patient Over Major Cardiac Risk

Ahospital in France has had to stop an experimental treatment using hydroxychloroquine on at least one coronavirus patient after it became a "major risk" to their cardiac health. Professor émile Ferrari, the head of the cardiology department at the Pasteur hospital in Nice, said the side effects had already been identified, with some patients having to stop treatment because of the risk posed.

April 14, 2020, French Drug-Surveillance Specialist Highlights Hydroxychloroquine Risks

Government monitoring authorities in France have seen a jump in reports of serious side effects from hydroxychloroquine used to treat patients with Covid-19. Since March 27, the center in charge of tracking hydroxychloroquine has received notifications about 54 Covid-19 patients who developed serious heart problems while taking the drug. Four died.

3.3.6.. Brazilian hospital killed patients by higher dose of chloroquine in 600 milligrams

The death may be caused by improper dosage.

April 12, 2020, Brazilian, Universidade do Estado do Amazonas, maylagsborba@gmail.com published article Small Chloroquine Study Halted Over Risk of Fatal Heart Complications.

The Brazilian study involved 81 hospitalized patients in the city of Manaus and was sponsored by the Brazilian state of Amazonasm, was halted early for safety reasons after coronavirus patients taking a higher dose of chloroquine developed irregular heart rates that increased their risk of a potentially fatal heart arrhythmia.

Roughly half the study participants were given a dose of 450 milligrams of chloroquine twice daily for five days, while the rest were prescribed a higher dose of 600 milligrams for 10 days.

Within three days, researchers started noticing heart arrhythmias in patients taking the higher dose. By the sixth day of treatment, 11 patients had died, leading to an immediate end to the high-dose segment of the trial.

The researchers said the study did not have enough patients in the lower-dose portion of the trial to conclude if chloroquine was effective in patients with severe disease. More studies evaluating the drug earlier in the course of the disease are “urgently needed,” the researchers said.

Despite its limitations, infectious disease doctors and drug safety experts said the study provided further evidence that chloroquine and hydroxychloroquine, which are both used to treat malaria, can pose significant harm to some patients, specifically the risk of a fatal heart arrhythmia. Patients in the trial were also given the antibiotic azithromycin, which carries the same heart risk. Hospitals in the United States are also using azithromycin to treat coronavirus patients, often in combination with hydroxychloroquine.

Several clinical trials for chloroquine and hydroxychloroquine are testing low doses for shorter periods of time in coronavirus patients. But the Health Commission of Guangdong Province in China had initially recommended those sick with the virus be treated with 500 milligrams of chloroquine twice daily for 10 days.

One of the authors of the Brazilian study, Dr. Marcus Lacerda, said in an email on Sunday that his study found that “the high dosage that the Chinese were using is very toxic and kills more patients.”

“That is the reason this arm of the study was halted early,” he said, adding that the manuscript was being reviewed by the journal Lancet Global Health.

“To me, this study conveys one useful piece of information, which is that chloroquine causes a dose-dependent increase in an abnormality in the ECG that could predispose people to sudden cardiac death,” said Dr. David Juurlink, an internist and the head of the division of clinical pharmacology at the University of Toronto, referring to an electrocardiogram, which reads the heart’s electrical activity.

Dr. Bushra Mina, the section chief of pulmonary medicine at Lenox Hill Hospital in Manhattan, said the study would most likely not change his hospital’s practice of giving a five-day course of hydroxychloroquine and azithromycin to hospitalized patients who were not severely ill. Dr. Mina said patients are monitored daily for heart abnormalities and the drugs are stopped if any are found.

4.. By saving immune system cured critically ill COVID-19 patient

April 14th, 2020, Doctors may have discovered another life-saving coronavirus drug

A 44-year-old ER doctor in Seattle developed a life-threatening case of COVID-19 was saved with anti-inflammatory drug Actemra to have reduced the “cytokine storm” and discharged after nearly a month in the hospital.

The drug has been used in China and might be tested on more COVID-19 patients.

Dr. Ryan Padgett from the EvergreenHealth Medical Center in Seattle is one of those exceptions to the rule when it comes to COVID-19 severity.

On March 12th, he became a patient in his hospital and was soon put on a ventilator after experiencing difficulty breathing. His lungs and kidneys started failing five days after that, and his heart was set to follow. Padgett’s colleagues gave him a day or so to live. That’s when they decided to test an experimental treatment that had also been tested in China on the sickest COVID-19 patients.

Padgett was likely experiencing a cytokine storm, a phenomenon that doctors treating COVID-19 patients are still trying to understand. Basically, the immune system’s response is so strong that it turns the body against itself, doing more harm than good in the latter stages of the disease.

That’s when the doctors tried a drug called Actemra, which was designed for rheumatoid arthritis, but was approved in 2017 to treat the same cytokine storm phenomenon that can appear in cancer patients.

After four days on the drug and other therapies, the levels of blood oxygen improved, and on March 23rd, Padgett was taken off life support. After four more days, they removed his breathing tube, and he came out of his sedated coma. Padgett was discharged on April 5th.

The same team was able to treat a 33-year-old woman who was dealing with her own cytokine storm by using the same combination of drugs.

Other anti-inflammatory drugs, such as Roche Holding’s Actemra, have shown signs of working on coronavirus patients who suffer from respiratory problems.

5.. The experts in Montreal Clinical Research Institute must provide support for clinic

The use of new medication in clinic will face many legal limitations, which will badly affect the quick clinical application of the effective treatment, but under the name of clinical trial as scientific research will make everything possible.

In this concern, the experts in Montreal Clinical Research Institute should immediately cooperate with Montreal Jewish General Hospital that has designated as the treatment for the patients with new coronavirus pneumonia.

The experts of IRCM and Montreal Jewish General Hospital should be authorized to directly use some treatment into clinic without the approval of the Drug Regulatory Agency of Federal Government.

Then the successful experiences should be immediately published to support the treatment globally.

The greatest contribution of Canada to the people globally is not from what Made in Canada by purify natural medicinal to bad from good, but from the rationally practice by promoting existing medications into clinic use.

6.. An apologized explanation to the specialist of China

After repeated painful consideration, I decided to mention the specialist with this explanation as paid apologies.

In this topic, I took him as an example to illustrate the limitation of the Western medicine, in this brutal battle of saving lives from the hand of the dead virus, those most famous experts in Western Medicine may be in playing counterproductive role due to that they dogmatically addicted in the game of killing by mindlessly expelling effective experience based medications with the pretext of unscientific.

The mistake of the specialist may act as powerful hammer to waken up those medical experts in Western Medicine globally by knocking their head, because of that the most of them are occupying the ruling position in deciding the medication for rescuing patients, they must immediately give up their addicted virus killing and turn to immune boosting.

I would like to say thank to specialist for his helping to knock the heads of some medical experts and to waken them up to save life by doing right business.

7.. The experiences from China, Serbia and Italy

8.1.. Mar. 15, 2020, Why China has successfully contained epidemic of COVID-19

8.2.. Mar. 29, 2020, The zero contact in the epidemic control of China

8.3.. The video mad by Japanese people in introducing about virus prevention measures in Nanjing, China

8.4.. Mar. 25, 2020, Serbia built temp-hospital by exhibition center on the advice of Chinese experts

8.5.. Mar. 15, 2020, Why Italy has so many people infected and being killed

8.6.. Mar. 26, 2020, Wearing mask is the best way for containing the epidemic

8.. About the writer Frank

I, I am Frank, a senior researcher on metal materials once worked in a big Research Institute of China, once as colleague worked in same department of Zhang Xiaogang of the former CEO of ISO, which may make people easily learnt my worked Institute from the background of Zgang Xiaogang.

The biggest gain from my research career was that I have been forced and exercised to be able to calm the mind with an ability of long time concentrated on delving into specific subject until being made clear.

My career time spent more in Libraries then Laboratories, and the most of spare time spent on the study of Traditional Chinese Medicine - TCM, especially, those modern findings of bioactive substances and their pharmacological effects of the natural medicinals that identified as medicinal use.

People trusted mainstream Western medicine (WM) takes Reductionism as guidance and which regards human body as a mechanical combination of inanimate parts, in attempts to reveal the mechanism of life and disease with infinitely subdivided micro-units as protein or gene in ignoring the decisive role of human autoimmunity and psychological factors in the development of diseases. The treatment is mainly by looking for killing. Due to the mutation of the pathogens is too rapid to be contained, WM has increasingly helpless.

The philosophy of TCM is Daoism that is exactly in opposite of the Reductionism; it cherishes human body as a organic whole and all organs are closely interconnected and in inter-influencing, the psychological factors are playing decisive role in the disease development with thousands years believe that treatment is seven tenth in psychotherapy, only three tenth in medication and by trying to restore the balance of yin and yang of human body as the treatment. It is the correct philosophy in guiding Chinese medicine to successfully save lives and increasingly welcomed globally.

Through trial and error clinically, under holistic philosophy Daoism, in past thousands of years, TCM developed many natural curatives that focus on bringing back the natural balance of body, such as, natural medicinals, acupuncture, massage and physical exercises, etc., with identified about 11,146 medicinal plants, 1581 medicinal animals and 80 medicinal minerals with nearly 100 thousands of experience based formulas in covering almost all known diseases.

In fact, in the process of human struggle for survival, no matter which ethnic group, they all developed their own medical methods, but only the people of China made written records since ancient time. Oct. 2, 2014, in article Why did China not produce harmful native religions, I indicate that “people appreciate the 5,000 years continuous civilization of China, however, most of people have overlooked the nature of the civilization, the valuable point, is not in the length of time, but, in the continuously documented historical facts – the facts in success and failure made valuable references, so that the future generations will avoid to repeat mistakes with lesser Detour.”

Below photos were two of my collections of TCM books in modern findings on Chinese medcinals.

The book name in photo 1 was The Pharmacology and Clinical Application of Chinese Medicine; the size of paper was in B5 with 752 pages, only Issued 3,000 copies in 1999. It was the collections of the results of modern studies on pharmacology and clinical application on 1070 of natural Chinese medicinals by using modern biotechnologies of Western medicine.

The book name in photo 2 was The Trace Chemical Elements and Chinese Medicine; the size of paper was in B5 with 483 pages, only issued 6,000 copies in 1993. It was the collections of the results of modern studies on the Trace Chemical Elements in natural Chinese Medicinals.

When studying TCM, I have inevitably involved some studies in western medicine with comparison of two medical systems in philosophy, definition, diagnosis, medications and treatments, which inspired me to write some articles.

Dec. 21, 2011, Chinese Medicine - A Promising Therapeutic Approach

Jun. 26, 2018, The approaches for enhancing the social cornerstones of Canada

Jan. 26, 2020, Vinegar, Vc, B3, and Chinese medicinals is the best curative for 2019 new coronavirus.

Above is the origin of my confidence that encourages me dared to talk about the treatment of 2019 novel coronavirus pneumonia with a background of metal materials.

In China, the epidemic of COVID-19 has been basically controlled and now is in hardly fighting against inbound source of infections, the daily life of people is gradually returning to normal, there are more and more enterprises returning full production to meet the needs of the people globally.

This should thank the effective prevention and treatment, especially should thank that people willingly wear mask to prevent the spread of dead virus and Chinese medicinals cured people massively.

The success of China shows that COVID-19 is preventable and treatable; the key is at right procedures and powerful execution.

Why I wrote this article

I write this article is not from the fear of death, but from the fear of psychological harm caused by kinship death to family members globally. I live in Canada and my parents were in China. In their later years, my father spoke clearly, but heard unclear, and my mother heard well, but, spoke unclear, and every time made phone call was psychological torment to me.

Later, my father died of liver cancer, my mother died suddenly of a large myocardial infarction.

I left home at my 17; working and studying outside, each year only have a few days in Chinese New Year to reunite with my parents. After my parents died, I thought about things that I should have done but without the opportunity to be done for my parents, which caused me sustained in the state of self-blame and formed habitual tears.

Sep. 11, 2014, in article The death of a Canadian business owner, I indicate that, “people will experience many things in the lifetime, many of them would be forgotten, but some of them can never be forgotten, and often, they are haunting in the mind, some of them are happy, but the most of them are sad. Maybe, this is the part of life.”

Now, under the dead virus, many people in many countries are in suffering what I have suffered in the past.

My parents died mainly because they were older, and now, some of the deceased under virus are younger. All of this could have been avoided, as long as active prevention for avoiding the infection. Such as, in Iran, the Chinese factories there no employee was infected due to the active prevention by the methods of domestic China, regularly environmental disinfection, and everyone wears mask.

The links of some of my writings

Vinegar, Vitamin C, B3, and Chinese medicinals is the best curative for COVID-19

Chinese Medicine - A Promising Therapeutic Approach

The approaches for enhancing the social cornerstones of Canada

Wearing mask is the best way for containing the epidemic

Some medical experts are in acting as the Killer aid of SARS-CoV-2

瀏覽(559)