Mechanism of vinegar cures depression & psychosis Frank Li Sep 11 2026
https://blog.creaders.net/user_blog_diary.php?did=NTY4MzA0
In Canada; during the last century, Dr. Abram Hoffer using megadose niacinamide or niacin cured schizophrenia; and which promoted the birth of the Orthomolecular Medicine. Now, the therapeutic mechanism was revealed. Vingar, psychosis, and niacinamide Google by keyword: vinegar , psychosis, niacinamide
AI Overview
Vingar, psychosis, and niacinamide (a form of vitamin B3)intersect primarily through recent scientific findings in metabolomics and historical theories in orthomolecular psychiatry[1, 2] Here is how these three concepts connect based on clinical research: 1. The Vinegar and Niacinamide Connection Clinical trials, including a notable study from Arizona State University, discovered that daily liquid vinegar ingestion significantly increases serum niacinamide (nicotinamide) concentrations. [1, 2] The Result: This metabolic shift caused an average 86% increase in niacinamide levels in participants, which directly correlated with a significant reduction in depressive symptoms. [1, 2, 3]
2. The Niacinamide and Psychosis Connection The relationship between vitamin B3 (niacin or niacinamide) and psychosis centers on two medical areas: The Niacin Flushing Test: Psychiatrists use a skin test with niacin as a biological marker for schizophrenia and psychosis risk. Most healthy individuals experience temporary skin flushing (redness) from niacin. However, a significant subset of individuals with schizophrenia exhibit "niacin blunting"—an abnormally low or absent flushing response caused by disrupted prostaglandin and fatty acid signaling. [1, 2, 3, 4]
Orthomolecular History: In the 1950s, a movement called orthomolecular psychiatry hypothesized that megadoses of vitamin B3 (niacin or niacinamide) could treat schizophrenia by altering adrenaline metabolism. While modern mainstream medicine treats psychosis with standardized antipsychotic medications, clinical researchers still study a rare "niacin-dependent" subset of psychiatric symptoms, such as severe niacin deficiency (pellagra), which can cause profound hallucinations, delusions, and psychosis. [1, 2, 3, 4]
Summary of the Intersection | Component | Direct Biological Role | Mental Health Context |
|---|
| Vinegar | Upregulates the NAD+ salvage pathway. | Substantially raises blood niacinamide levels; clinically shown to improve mood. | | Niacinamide | A non-flushing form of Vitamin B3. | Historically used in megadose psychiatric therapies; essential for neuroprotection. | | Psychosis | Severe psychiatric state often featuring delusions. | Associated with a blunted physical response to niacin and severe B3 deficiency states. |
Above was AI Overview Vinegar improve the condition of depression By increasing the niacinamide in the metabolites by oral 2.95 g vinegar in twice daily. In 2024, the US Arizona State University published study Daily Vinegar Ingestion Improves Depression and Enhances Niacin Metabolism in Overweight Adults: A Randomized Controlled Trial. Methods The participants in the treatment group dilute 30 mL (2 tablespoons) contained 2.95 g acetic acid in a cup of water twice daily and ingest at the first bites of a meal. The participants in the control group received vinegar pills contained 22.5 mg acetic acid, an inactive dose. Results Of the remaining metabolites the raw data revealed that niacinamide and L-isoleucine displayed the greatest change during the trial for VIN participants, +86% and −35% respectively, and these changes were inversely correlated (r = −0.698 [Spearman's rho]; p < 0.001). Conclusions These data provide additional support that daily vinegar ingestion over four weeks can improve self-reported depression symptomology in generally healthy adults and that alterations in niacin metabolism may factor into this improvement. The origin of the Orthomolecular Medicine
Nowadays, various vitamins, multivitamins, minerals, and nutritional supplements have become widely popular. Those are called Orthomolecular Medicine that was coined in 1968 by two-time Nobel Prize winner Dr. Linus Pauling, the term means "right molecule", correct or right. Core Theory: Disease is viewed as a reflection of nutritional or biochemical imbalances in the body. Practitioners attempt to correct these via individualized diagnostics and high-dose nutritional or "megavitamin" therapies. Common Substances: Treatments frequently utilize high doses of Vitamin C, Vitamin E, Coenzyme Q10, alpha-lipoic acid, zinc, and essential fatty acids. Vitamins, minerals, amino acids, trace elements and fatty acids will be the best treatment for the most of diseases; the key is at the high concentration in blood, which needs intravenous infusion in use or oral megadose in g/kg body weight. The budding of Orthomolecular Medicne in Canada Dr. Abram Hoffer, the initiator of the use of the megavitamin therapy Abram Hoffer (1917 – 2009) was a Canadian biochemist, physician, and psychiatrist known for his "adrenochrome hypothesis" of schizoaffective disorders. According to Hoffer, megavitamin therapy and other nutritional interventions are potentially effective treatments for schizophrenia and other diseases.[citation needed]. Hoffer was also involved in studies of LSD as an experimental therapy for alcoholism; the discovery that high-dose niacin can be used to treat high cholesterol and other dyslipidemias. Hoffer uses megadose B3 to cure schizophrenia; the results were excellent. William Wilson, the setter for the promotion of megavitamins Bill Wilson (1895 – 1971), an alcoholic addiction. He was the co-founder of Alcoholics Anonymous (AA). AA is an international mutual aid fellowship with about 2 million members worldwide belonging to approximately 10,000 groups, associations, organizations, cooperatives, and fellowships of alcoholics helping other alcoholics achieve and maintain sobriety. In 1960, New York, Abram Hoffer introduced to Bill that high-dose vitamins could help alcoholics. Bill started taking niacin 3 grams per day. Within weeks, the fatigue and depression that had afflicted him for years disappeared. He assigned niacin to his 30 good friends to try, and they all achieved the same effect. Then Bill promoted the use of megavitamins in AA. Later, Bill was excluded from AA members. These Bill-appointed doctor members felt he had no reason to use vitamins as a cure. For this reason, in December 1965, he wrote to distribution to AA members, in which he used B-3, and the name B-3 is popular used now globally.
Wilson conduct a group of mentally ill alcoholic use B3, and result was satisfied, then wrote paper The Vitamin B-3 Therapy: A Promising Treatment for Schizophrenia – and its high relevance to the field of alcoholism in December 1965. In 2003, I special went Centre for Addiction and Mental Health, CAMH Library, Toronto, copied the paper. The cover is as follow. (A.A. - Alcoholics Anonymous). 
Dr. Linus Pawling, the proposer of the Orthomolecular Medicine The paper inspired two-time Nobel Prize winner American chemist Dr. Linus Pauling, who coined Orthomolecular Medicine in his 1968 article Orthomolecular Psychiatry in the journal "Science" after read the paper of Bill Wilson.
Dr. Linus Carl Pawling 1901 –1994) was an American chemist, biochemist, chemical engineer, peace activist, author, and educator. He published more than 1,200 papers and books, of which about 850 dealt with scientific topics. New Scientist called him one of the 20 greatest scientists of all time, and as of 2000, he was rated the 16th most important scientist in history. For his scientific work, Pauling was awarded the Nobel Prize in Chemistry in 1954. For his peace activism, he was awarded the Nobel Peace Prize in 1962.
Pauling was one of the founders of the fields of quantum chemistry and molecular biology.[9] His contributions to the theory of the chemical bond include the concept of orbital hybridisation and the first accurate scale of electronegativities of the elements. Pauling also worked on the structures of biological molecules, and showed the importance of the alpha helix and beta sheet in protein secondary structure.
Pauling's approach combined methods and results from X-ray crystallography, molecular model building, and quantum chemistry. His discoveries inspired the work of James Watson, Francis Crick, and Rosalind Franklin on the structure of DNA, which in turn made it possible for geneticists to crack the DNA code of all organisms. In his later years he promoted nuclear disarmament, as well as orthomolecular medicine, megavitamin therapy, and dietary supplements. None of the latter have gained much acceptance in the mainstream scientific community, but got a lot of criticizing and being refused to fund his clinical trial. Dr. Abram Hoffer; Bill Wilson and Linus Pauling were attacked Here I have to indicate the evil of Western medicine trained people, Dr. Abram Hoffer and Bill Wilson were both attacked due to advocate the use of B3 and ousted from their job position. Please Google online; there are still a lot of articles in condemning Linus Pauling regarding the use of the Orthomolecular Medicine. Modern studies showed that Orthomolecular medicine has full cover therapeutic effects, such as: The OM was originally intended to treat the “mental disease by the provision of the optimal molecular environment of the mind, especially the optimal concentrations of substances normally present in the human body.” OM currently is called as diet supplements that have developed many products, such as, Vitamins, minerals and so on. Linus Paulin who published the Nature of the chemical bond in 1939. Later he did many pioneering works in understanding the nature of life from atomic structure, binding mode between atoms, nucleic acids and proteins. Whether from chemical, biological, and medical, he has laid a solid theoretical foundation. Vitamin B-3 has wide range of physiological improvement functions. Its therapeutic process for psychotic is to restore damaged brain rather than as that of antipsychotic drugs control the abnormal secretions in the brain. Naturally, OM treats the diseases in a Holistic way. Although, for decades, some people have been eagerly trying to deny the curative effect of OM, however, the physiological improvement function is coming clearer in both clinic and academic. Now it gains extensively application world widely. Vitamin C was the one of OM, which was Linus Pauling strongly recommended, also was strongly opposed by others. following are some of new researches on Vitamin C. 1. Vitamin C Saves Lives! After Linus Pauling wrote his book on vitamin C in 1970, mortality from heart disease decreased 30-40% in the USA. From around 741,000 deaths per year to less than 500,000 deaths by 1986 - U. S. Bureau of National Health Statistics 1986.
2. Vitamin C may be useful to treat cancer after all. 3. Study shows vitamin C's cancer-fighting properties. 4. Vitamin C beneficial in cancer treatment – study. 5. How Vitamin C Stops Cancer. In TCM, there are variety of nutritional constituents that are far more than that of in OM, which come from more than 10 thousands of plants, minerals and animals, such as, Ginseng, Gypsum and Placenta. They are certainly playing a significant role in the diseases treatment, but their unique contribution seems to have been ignored both clinically and academically. The reason may come from the TCM itself because that it never distinguishes the medicinal and nutritional, even without the concepts and terms, they were generally called as medicine. In western medicine, Chinese medicinals generally called as alternative or diet supplements. I think that there is necessary to make a definition, such as, those with the effect of killing pathogenic agents should be called as medicinal, and those without the effect of killing pathogenic directly but with the role of physiological improvement should be called as nutritional, include those in Western medicine. A clear concept with a exact term will not only help clear describing, but also conducive to efficient thinking. The determination of a definition is difficult that need to be discussed carefully because of the ingredient of many single herbs is compound that contains both medicinal and nutritional. Even if a single constituent also has a dual role, such as, some peptide is nutritional but also an antibiotic. The nutritionals in Chinese medicinals is a promising medical potential to be an attractive research direction.
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