Healthy dietary patterns, longevity genes, and life expectancy: A prospective cohort study

——《科學進展》第12卷，第7期，2026年2月13日——

<Science Advances> Volume 12, Issue 7, 13 Feb. 2026

【摘要】健康飲食模式與預期壽命之間的關聯尚不明確。本研究報告了五種飲食模式與英國生物銀行103,649名參與者死亡率和預期壽命的前瞻性關聯。在中位數為10.6年的隨訪期內，共記錄到4314例死亡。替代健康飲食指數-2010、替代地中海飲食（AMED）、健康植物性飲食指數（hPDI）、膳食療法控制高血壓和糖尿病風險降低飲食（DRRD）均與較低的全因死亡率和較長的預期壽命相關，其中DRRD的關聯性略強於hPDI。與最低五分之一人群相比，達到最高五分之一飲食評分的人群在45歲時預期壽命可延長1.9至3.0年（男性）和1.5至2.3年（女性）。男性採用DRRD飲食方案時預期壽命延長最長，女性採用AMED飲食方案時預期壽命延長最長。即使考慮了遺傳易感性，這些顯著關聯仍然存在。我們的研究結果強調了健康飲食模式在延長預期壽命方面的優勢，而與長壽基因無關。

[Abstract] Associations between healthy dietary patterns and life expectancy remain unclear. Here, we reported the prospective associations of five dietary patterns with mortality and life expectancy in 103,649 UK Biobank participants. Over a median follow-up period of 10.6 years, 4314 total deaths were documented. Alternate Healthy Eating Index-2010, Alternate Mediterranean Diet (AMED), healthful Plant-based Diet Index (hPDI), Dietary Approaches to Stop Hypertension, and Diabetes Risk Reduction Diet (DRRD) were associated with lower all-cause mortality and longer life expectancy, with DRRD showing slightly stronger associations than hPDI. Compared with the bottom quintile, achieving the top quintile of dietary scores was associated with 1.9 to 3.0 years of life gained at 45 years in men and 1.5 to 2.3 years in women. The life gained was longest in DRRD for males and AMED for females. The significant associations remained when accounting for genetic susceptibility. Our findings underscore the advantages of healthy dietary patterns in prolonging life expectancy, regardless of longevity genes.

論文原文：Yanling Lv, Jing Song, Ding Ding, et al (2026). Healthy dietary patterns, longevity genes, and life expectancy: A prospective cohort study. Science Advances, Volume 12, Issue 7. 13 February 2026.

https://doi.org/10.1126/sciadv.ads7559  

（翻譯兼責任編輯：MARY）

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